N-Boc-L-脯氨醇合成路线 （共 100 条）
反应条件
1: H2, HCl / 10percent Pd/C / methanol / 760 Torr 2: diethyl ether View Scheme
参考文献
Journal of the American Chemical Society, , vol. 118, # 26 p. 6297 - 6298
反应条件
triethylamine in dichloromethane
反应条件
1: 1-(tert-butoxycarbonyl)-L-proline With sodium hydride in tetrahydrofuran T=20°C; 1 h; 2: benzyl bromide in tetrahydrofuran T=20°C; 20 h;
参考文献
Dubey, Rajeev K.; Niemi, Marja; Kaunisto, Kimmo; Efimov, Alexander; Tkachenko, Nikolai V.; Lemmetyinen, Helge
Chemistry - A European Journal, 2013 , vol. 19, # 21 p. 6791 - 6806
反应条件
sodium tetrahydroborate; iodine in tetrahydrofuran T=0 - 20°C; 5.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 12 p. 2571 - 2578
反应条件
1: With ozone in methanol; dichloromethane T=-78°C; 0.833333 h; 2: With sodium tetrahydroborate in methanol; dichloromethane T=0°C; 3.5 h;
参考文献
Yamamoto, Satomi; Sugimoto, Hiroshi; Tamura, Osamu; Mori, Tatsuya; Matsuo, Noritada; Ishibashi, Hiroyuki
Tetrahedron, 2004 , vol. 60, # 40 p. 8919 - 8927
反应条件
1: 94 percent / triethylamine / CH2Cl2 / 2.5 h / 0 °C 2: 82 percent / borane-tetrahydrofuran complex / tetrahydrofuran / 3 h / 0 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 67, # 25 p. 9111 - 9114
反应条件
tert.-butylnitrite; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone in chlorobenzene T=100°C; P=760.051 Torr; 7 h;
参考文献
Tetrahedron Letters, , vol. 54, # 12 p. 1579 - 1583
参考文献
US6437138 B1, ;
US 6437138 B1
反应条件
sodium tetrahydroborate in water T=0°C;
参考文献
Jadhav, Sandip V.; Bandyopadhyay, Anupam; Benke, Sushil N.; Mali, Sachitanand M.; Gopi, Hosahudya N.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 11 p. 4182 - 4187
