N-Boc-L-脯氨醇合成路线 （共 100 条）
反应条件
1: 56 percent / lithium di-isopropylamide, HMPA / tetrahydrofuran 2: 88 percent / KOH / methanol / 16 h / Ambient temperature 3: 20 percent / Et3N, diphenylphosphoryl azide / toluene / 7 h / Heating 4: Heating 5: 1.) O3; 2.) NaBH4 / 1.) CH2Cl2, -15 deg C, 8 min; 2.) EtOH, 0 deg C, 1.5 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2299 - 2306
反应条件
1: 88 percent / KOH / methanol / 16 h / Ambient temperature 2: 20 percent / Et3N, diphenylphosphoryl azide / toluene / 7 h / Heating 3: Heating 4: 1.) O3; 2.) NaBH4 / 1.) CH2Cl2, -15 deg C, 8 min; 2.) EtOH, 0 deg C, 1.5 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2299 - 2306
反应条件
1: 2: With diisobutylaluminium hydride
参考文献
European Journal of Organic Chemistry, , # 20 p. 4399 - 4404
反应条件
lithium aluminium tetrahydride
参考文献
Tetrahedron Letters, , vol. 41, # 51 p. 10131 - 10134
反应条件
1: 77 percent / 48 h / Heating 2: 1.) O3; 2.) NaBH4 / 1.) CH2Cl2, -15 deg C, 8 min; 2.) EtOH, 0 deg C, 1.5 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2299 - 2306
反应条件
sodium tetrahydroborate; ozone 1.) CH2Cl2, -15 deg C, 8 min; 2.) EtOH, 0 deg C, 1.5 h; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2299 - 2306
反应条件
1: 96 percent / Et3N / CH2Cl2 / 12 h / 20 °C 2: 54 percent / LiEt3BH / tetrahydrofuran / Heating 3: 96 percent / HCl gas / ethyl acetate / 2 h / 20 °C View Scheme
参考文献
Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589
反应条件
1: 96 percent / Et3N / CH2Cl2 / 12 h / 20 °C 2: 54 percent / LiEt3BH / tetrahydrofuran / Heating 3: 96 percent / HCl gas / ethyl acetate / 2 h / 20 °C 4: K2CO3 / acetonitrile / 6 h / Heating 5: CuI; (i-Pr)2NH / PdCl2(PPh3)2 / acetonitrile / 20 °C View Scheme
参考文献
Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Cooling with iceReflux;
参考文献
SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.
Patent: US2012/165352 A1, 2012 ;
Location in patent: Page/Page column 23-24 ;
反应条件
1: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere 2: 2-pentafluorophenyl-6,17dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 168 h / 20 °C / Inert atmosphere View Scheme
参考文献
Thai, Karen; Wang, Li; Dudding, Travis; Bilodeau, Francois; Gravel, Michel
Organic Letters, 2010 , vol. 12, # 24 p. 5708 - 5711
