N-Boc-L-脯氨醇合成路线 （共 100 条）
反应条件
1.1: NaH / tetrahydrofuran / -78 °C 1.2: 77 percent / tetrahydrofuran / 20 h / -78 - 20 °C 2.1: TFA / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Kopka, Klaus; Faust, Andreas; Keul, Petra; Wagner, Stefan; Breyholz, Hans-Joerg; Hoeltke, Carsten; Schober, Otmar; Schaefers, Michael; Levkau, Bodo
Journal of Medicinal Chemistry, 2006 , vol. 49, # 23 p. 6704 - 6715
反应条件
oxalyl dichloride; dimethyl sulfoxide in triethylamine
参考文献
Ikeda, Masazumi; Shikaura, Jiro; Maekawa, Noriko; Daibuzono, Kaori; Teranishi, Hirotaka; Teraoka, Yoshiko; Oda, Norio; Ishibashi, Hiroyuki
Heterocycles, 1999 , vol. 50, # 1 p. 31 - 34
反应条件
triethylamine in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dimethyl sulfoxide
参考文献
Arizona Board of Regents
Patent: US4978744 A1, 1990 ;
反应条件
anhydrous sodium hydrogen carbonate; triethylamine in dichloromethane
参考文献
Peschke, Bernd; Pettersson, Ingrid
Patent: US2003/195190 A1, 2003 ;
US 20030195190 A1
参考文献
Hoffmann-La Roche Inc.
Patent: US6130239 A1, 2000 ;
US 6130239 A
反应条件
1.1: 98 percent / Et3N / tetrahydrofuran / -15 - 20 °C 2.1: n-BuLi / tetrahydrofuran / 1 h / 0 °C 2.2: 50 percent / tetrahydrofuran / 1 h 3.1: 340 mg / trifluoroacetic acid / 0.67 h View Scheme
参考文献
Hiroi; Abe
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 3 p. 616 - 621
反应条件
pyridine; N-bromosuccinmide; triphenylphosphine in dichloromethane T=20°C;
参考文献
CHROMA THERAPEUTICS LTD
Patent: WO2006/117552 A1, 2006 ;
Location in patent: Page/Page column 170-171 ;
WO 2006/117552 A1
反应条件
2,4,6-trichloro-1,3,5-triazine; N,N-dimethyl-formamide; sodium bromide in dichloromethane T=25°C; 0.666667 h;
参考文献
De Luca, Lidia; Giacomelli, Giampaolo; Porcheddu, Andrea
Organic Letters, 2002 , vol. 4, # 4 p. 553 - 555
反应条件
1: N-(tert-butyloxycarbonyl)-L-prolinol With 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; potassium hydrogencarbonate; potassium bromide in dichloromethane; water T=0 - 5°C; 0.166667 h; Inert atmosphere; 2: With sodium hypochlorite in dichloromethane; water T=0 - 5°C; 1 h; Inert atmosphere; 3: ethane-1,2-dial With ammonium hydroxide in acetonitrile T=0 - 20°C; 19 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 16, # 9 p. 2310 - 2313
反应条件
1: sodium hydrogencarbonate; sodium hypochlorite; 2,2,6,6-tetramethyl-piperidine 1-oxide; sodium bromide / dichloromethane / 1 h / 0 °C 2: ammonia / water; methanol / 22 h / 10 °C View Scheme
