N-Boc-L-脯氨醇合成路线 （共 100 条）
反应条件
1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide; chlorine; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / dichloromethane / 1 h / 0 °C 2: ammonia / water; methanol / 10 °C 3: N-bromosuccinmide / dichloromethane / 3 h / -10 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; COBURN, Craig A.; WU, Hao; HU, Bin; ZHONG, Bin; WANG, Dahai; XU, Zaixu; SUN, Fei; JI, Tao; DAN, Zhigang
Patent: WO2012/3642 A1, 2012 ;
反应条件
1: 100 percent / Et3N / CH2Cl2 / 3 h / 20 °C 2: 55 percent / NaN3 / dimethylformamide / 18 h / 60 °C 3: 100 percent / H2 / Pd/C / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Slaitas; Yeheskiely
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1377 - 1379
反应条件
1H-imidazole; diphenylphosphinopolystyrene; iodine in dichloromethane 1 h; Heating;
参考文献
Bolognese, Adele; Fierro, Olga; Guarino, Daniela; Longobardo, Luigi; Caputo, Romualdo
European Journal of Organic Chemistry, 2006 , # 1 p. 169 - 173
反应条件
iodine; triphenylphosphine in tetrahydrofuran; n-heptane
参考文献
Dull, Gary Maurice; Schmitt, Jeffrey Daniel; Bhatti, Balwinder Singh; Miller, Craig Harrison
Patent: US2002/58652 A1, 2002 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Cooling with iceReflux;
参考文献
SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.
Patent: US2012/165352 A1, 2012 ;
Location in patent: Page/Page column 23-24 ;
反应条件
1: SO3; pyridine; DIPEA / dimethylsulfoxide; CH2Cl2 / 5 h / -5 °C 2: PPh3 / CH2Cl2 / 2 h / -5 - 0 °C 3: 83 percent / n-BuLi / tetrahydrofuran / 1.25 h / -78 °C View Scheme
参考文献
Cossy, Janine; Cases, Manuel; Pardo, Domingo Gomez
Bulletin de la Societe Chimique de France, 1997 , vol. 134, # 2 p. 141 - 144
反应条件
tert.-butylhydroperoxide; copper(l) chloride in decane; acetonitrile T=20°C;
参考文献
Mannam, Sreedevi; Sekar, Govindasamy
Synthetic Communications, 2010 , vol. 40, # 19 p. 2822 - 2829
反应条件
1: 87 percent / SO3*pyridine, Et3N / dimethylsulfoxide / 2.5 h / 7 - 8 °C 2: 1.) i-Pr2N, n-BuLi, MgBr2*Et2O / 1.) THF, hexane, -78 deg C, 30 min; -78 deg C to r.t., 2 h; -78 deg C, 1 h, 2.) THF, -95 deg C, 2 h 3: 62 percent / BF3*Et2O / CH2Cl2 / 1 h / -78 °C 4: 57 percent / potassium tert-butoxide / tetrahydrofuran / 0.08 h / -20 - -15 °C 5: 94 percent / H2 / 10percent Pd/C / methanol / 12 h / Ambient temperature View Scheme
参考文献
Pettit, George R.; Singh, Sheo Bux; Herald, Delbert L.; Lloyd-Williams, Paul; Kantoci, Darko; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6287 - 6295
反应条件
1: 78 percent / TEA; DMAP / CH2Cl2 / 3 h / 0 °C 2: dimethylsulfoxide / 4 h / 90 °C View Scheme
参考文献
Toujas, Jean-Louis; Jost, Eric; Vaultier, Michel
Bulletin de la Societe Chimique de France, 1997 , vol. 134, # 7 p. 713 - 718
反应条件
1: 96 percent / Et3N / CH2Cl2 / 12 h / 20 °C 2: 54 percent / LiEt3BH / tetrahydrofuran / Heating 3: 96 percent / HCl gas / ethyl acetate / 2 h / 20 °C View Scheme
参考文献
Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589
