N-Boc-L-脯氨醇合成路线 （共 100 条）
反应条件
1: pyridine 2: 18-crown-6 3: H2 / Raney-Ni View Scheme
参考文献
Kawara, Akihiro; Taguchi, Takeo
Tetrahedron Letters, 1994 , vol. 35, # 47 p. 8805 - 8808
反应条件
1.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide; chlorine; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / dichloromethane / 1 h / 0 °C 2.1: ammonia / water; methanol / 10 °C 3.1: sodium hydroxide; iodine / chloroform; water / 15 h / 20 °C 3.2: 40 h / Reflux View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao
Patent: WO2014/19344 A1, 2014 ;
参考文献
MITSUBISHI TANABE PHARMA CORPORATION
Patent: US2012/196824 A1, 2012 ;
反应条件
1.1: 83 percent / imidazole; PPh3; I2 / diethyl ether; CH2Cl2 / 16 h / 20 °C
2.1: Zn / N,N-dimethyl-acetamide; tetrahydrofuran / 2 h / -15 - 0 °C
2.2: H2O / N,N-dimethyl-acetamide
View Scheme
参考文献
Georgiou, Irene; Whiting, Andrew
European Journal of Organic Chemistry, 2012 , # 22 p. 4110 - 4113
反应条件
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Hsu, Shih-Fan; Ko, Chih-Wei; Wu, Yao-Ting
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 10 p. 1756 - 1762
反应条件
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
