N-Boc-L-脯氨醇合成路线 （共 100 条）
反应条件
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1: 85 percent / (COCl2), DMSO, Et3N
2: 82 percent / -78 °C
View Scheme
参考文献
Reddy, Kotha Kapu Sridhar; Rao, Batchu Venkateswara; Raju, Sagi Satyanarayana
Tetrahedron Asymmetry, 2011 , vol. 22, # 6 p. 662 - 668
反应条件
oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine
1.) CH2Cl2; 2.) DMSO; Yield given. Multistep reaction;
参考文献
Ikeda, Masazumi; Akamatsu, Susumu; Kugo, Yasuhiro; Sato, Tatsunori
Heterocycles, 1996 , vol. 42, # 1 p. 155 - 158
反应条件
1: 90 percent / pyridine / 0 °C
2: 88 percent / ethanol / Heating
View Scheme
参考文献
Chi, Dae Yoon; Katzenellenbogen, John A.
Journal of the American Chemical Society, 1993 , vol. 115, # 15 p. 7045 - 7046
