(S)-N-Boc-吡咯烷-2-甲醛 N-(叔丁氧羰基)-L-脯氨醛合成路线 （共 52 条）
反应条件
1: 79 percent / NaOH / dioxane 2: 93 percent / K2CO3 / dimethylformamide 3: 91 percent / DIBAH / toluene / -78 °C View Scheme
参考文献
Synlett, , vol. 1997, # 10 p. 1179 - 1180
反应条件
anhydrous sodium hydrogen carbonate; triethylamine in dichloromethane
参考文献
US2003/195190 A1, ;
US 20030195190 A1
反应条件
[rhodium(I)(carbonyl)2(acetylacetonate)]; hydrogen; (R,S)-Binaphos in benzene T=60°C; P=76000 Torr; 72 h; other reagent: (R)-2-(diphenylphosphino)-1,1'-binaphthalen-2'-yl (S)-3,3'-dimethyl-1,1'-binaphthalene-2,2'-diyl phosphite; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 62, # 13 p. 4285 - 4292
反应条件
1: Dess-Martin periodinane / CH2Cl2 / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 48 p. 8759 - 8763
反应条件
1: Et3N / CH2Cl2 2: 87 percent / Et3SiH / 10 percent Pd/C / acetone / 20 °C View Scheme
参考文献
Synthesis, , # 8 p. 1121 - 1123
反应条件
1: 91 percent / dimethylformamide / 4 h 2: 68.2 g / di-isobutylaluminium hydride / hexane / 0.5 h / -60 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2299 - 2306
参考文献
US6130239 A1, ;
US 6130239 A
反应条件
1: 8.5 g / NaHCO3, NaCl / CHCl3; H2O / 1.5 h / Heating 2: 63 percent / DIBAL-H / CH2Cl2; toluene / 1 h / -78 °C View Scheme
参考文献
Tetrahedron, , vol. 52, # 1 p. 225 - 232
反应条件
1: CH2Cl2 / 2 h / Ambient temperature 2: 96 percent / LiAlH4 / diethyl ether / 0.5 h / -10 °C View Scheme
参考文献
Heterocycles, , vol. 36, # 9 p. 2073 - 2080
反应条件
1: 4-(N,N-dimethlyamino)pyridine / acetonitrile / 2 h / 20 °C 2: Dess-Martin periodane / dichloromethane / 20 °C View Scheme
参考文献
Beilstein Journal of Organic Chemistry, , vol. 9, p. 818 - 826
