(S)-N-Boc-吡咯烷-2-甲醛 N-(叔丁氧羰基)-L-脯氨醛合成路线 （共 52 条）
反应条件
potassium carbonate in methanol T=4°C; Horner-Wadsworth-Emmons reaction; 48 h;
参考文献
Barrett, Anthony G. M.; Hopkins, Brian T.; Love, Andrew C.; Tedeschi, Livio
Organic Letters, 2004 , vol. 6, # 5 p. 835 - 837
反应条件
n-butyllithium; triphenylphosphine in tetrahydrofuran; hexane; dichloromethane; ethyl acetate
参考文献
Cuthbertson, James D.; Godfrey, Andrew A.; Taylor, Richard J. K.
Organic Letters, 2011 , vol. 13, # 15 p. 3976 - 3979
反应条件
1: diazomethyl-trimethyl-silane With lithium diisopropyl amide Metallation; 2: (S)-2-formylpyrrolidine-1-carboxylic acid tert-butyl ester Acetylenation;
参考文献
Pinto, Ivan L.; Boyd, Helen F.; Hickey, Deirdre M.B.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 2015 - 2017
反应条件
potassium permanganate; magnesium sulfate in acetone Yield given;
参考文献
Becker, Y.; Eisenstadt, A.; Stille, J. K.
Journal of Organic Chemistry, 1980 , vol. 45, # 11 p. 2145 - 2151
反应条件
1: DABCO / CH2Cl2 / 120 h / 20 °C / ultrasound 2: H2 / Pd/C / ethyl acetate / 20 °C 3: 70 percent / proton sponge / CH2Cl2 / 18 h / 20 °C 4: 86 percent / LiOH / tetrahydrofuran; H2O / 16 h / 20 °C View Scheme
参考文献
Pettit, George R.; Burkett, Douglas D.; Barkoczy, Jozsef; Breneman, Gary L.; Pettit, William E.
Synthesis, 1996 , # 6 p. 719 - 725
反应条件
potassium carbonate in methanol T=20°C; 15 h;
参考文献
Alcaide, Benito; Almendros, Pedro; Quiros, M. Teresa; Fernandez, Israel
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 818 - 826
反应条件
1: (2-oxo-propyl)-phosphonic acid dimethyl ester With 4-toluenesulfonyl azide; potassium carbonate in acetonitrile 2 h; 2: (S)-2-formylpyrrolidine-1-carboxylic acid tert-butyl ester in methanol; acetonitrile 8 h;
参考文献
MEDIVIR AB; AYESA, Susana; BELDA, Oscar; BJÖRKLUND, Catarina; NILSSON, Magnus; RUSSO, Francesco; SAHLBERG, Christer; WIKTELIUS, Daniel
Patent: WO2013/95275 A1, 2013 ;
Location in patent: Page/Page column 41; 42 ;
反应条件
potassium carbonate in methanol T=4°C; Horner-Wadsworth-Emmons reaction; 48 h;
参考文献
Barrett, Anthony G. M.; Hopkins, Brian T.; Love, Andrew C.; Tedeschi, Livio
Organic Letters, 2004 , vol. 6, # 5 p. 835 - 837
反应条件
n-butyllithium; triphenylphosphine in tetrahydrofuran; hexane; dichloromethane; ethyl acetate
参考文献
Cuthbertson, James D.; Godfrey, Andrew A.; Taylor, Richard J. K.
Organic Letters, 2011 , vol. 13, # 15 p. 3976 - 3979
反应条件
1: diazomethyl-trimethyl-silane With lithium diisopropyl amide Metallation; 2: (S)-2-formylpyrrolidine-1-carboxylic acid tert-butyl ester Acetylenation;
参考文献
Pinto, Ivan L.; Boyd, Helen F.; Hickey, Deirdre M.B.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 2015 - 2017
