1-(3,6-二羟基-2,4-二甲氧基苯基)-乙酮合成路线 （共 35 条）
反应条件
1: i-Pr2NEt / CH2Cl2
2: pyridine / 50 - 60 °C
3: KOH, pyridine / 80 °C
4: 89 percent / conc. H2SO4, AcOH / 60 °C
View Scheme
参考文献
TWINCORE GMBH; CNRS; UNIVERSITÉ DE STRASBOURG; PIETSCHMANN, Thomas; HAID, Sibylle; GENTZSCH, Juliane; GRETHE, Christina; DAVIOUD-CHARVET, Elisabeth; LANFRANCHI, Don Antoine; ELHABIRI, Mourad; BENLLOCH-MARTIN, Xavier
Patent: WO2013/139487 A1, 2013 ;
反应条件
1: 88 percent / potassium carbonate / dimethylformamide / 0.17 h / 160 °C
2: 87 percent / KOH / ethanol / 50 °C
3: 1.)Tl(NO3)3*3H2O, 2.)Na2SO3, 5percent HCl / 1.) CHCl3, 30 deg C, 24 h 2.) 0 deg C
4: H2 / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature
5: 68 percent / aq 10percent HCl / methanol / Heating
View Scheme
参考文献
Horie, Tokunaru; Sasagawa, Masahiro; Torii, Furaihito; Kawamura, Yasuhiko; Yamashita, Kazuyo
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 3 p. 486 - 491
反应条件
1: K2CO3 / acetone / Heating
2: pyridine / 3 h / 120 °C
3: KOH, pyridine / 4 h / 60 °C
4: 88 percent / AcONa, AcOH / 3 h / 140 - 145 °C
5: 97 percent / H2 / 10percent Pd/C / methanol; ethyl acetate
View Scheme
参考文献
Horie, Tokunaru; Tsukayama, Masao; Kourai, Hiroki; Yokoyama, Chieko; Furukawa, Masayuki; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2256 - 2262
反应条件
2: aq. KOH
View Scheme
参考文献
Stout,M.S. et al.
Journal of Pharmaceutical Sciences, 1964 , vol. 53, p. 192 - 195
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Iinuma, Munekazu; Matsuura, Shin; Tanaka, Toshiyuki
Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 4 p. 1472 - 1476
