2-叔丁基-5-氯-1H-吲哚合成路线 （共 5 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane
T=0 - 20°C; Cyclization; 9 h;
参考文献
Smith, Keith; El-Hiti, Gamal A.; Pritchard, Gareth J.; Hamilton, Anna
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 16 p. 2299 - 2303
反应条件
1: aq. NaHCO3 / CH2Cl2 / 3 h / 20 °C
2: ZnCl2 / 140 °C
View Scheme
参考文献
McKew, John C.; Foley, Megan A.; Thakker, Paresh; Behnke, Mark L.; Lovering, Frank E.; Sum, Fuk-Wah; Tam, Steve; Wu, Kun; Shen, Marina W. H.; Zhang, Wen; Gonzalez, Mario; Liu, Shanghao; Mahadevan, Anu; Sard, Howard; Khor, Soo Peang; Clark, James D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 135 - 158
反应条件
1: aq. NaHCO3 / CH2Cl2 / 3 h / 20 °C
2: ZnCl2 / 140 °C
View Scheme
参考文献
McKew, John C.; Foley, Megan A.; Thakker, Paresh; Behnke, Mark L.; Lovering, Frank E.; Sum, Fuk-Wah; Tam, Steve; Wu, Kun; Shen, Marina W. H.; Zhang, Wen; Gonzalez, Mario; Liu, Shanghao; Mahadevan, Anu; Sard, Howard; Khor, Soo Peang; Clark, James D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 135 - 158
反应条件
1: diethyl ether / 0.5 h / cooling
2: NEt3 / diethyl ether
3: LiAlH4 / tetrahydrofuran / 0.5 h / 10 °C
View Scheme
参考文献
McKew, John C.; Foley, Megan A.; Thakker, Paresh; Behnke, Mark L.; Lovering, Frank E.; Sum, Fuk-Wah; Tam, Steve; Wu, Kun; Shen, Marina W. H.; Zhang, Wen; Gonzalez, Mario; Liu, Shanghao; Mahadevan, Anu; Sard, Howard; Khor, Soo Peang; Clark, James D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 135 - 158
反应条件
1.1: diethyl ether / 0.5 h / cooling
2.1: NEt3 / diethyl ether
3.1: LiAlH4 / tetrahydrofuran / 0.5 h / 10 °C
4.1: NaH / dimethylformamide / 0.5 h / 0 °C
4.2: dimethylformamide / 0 - 20 °C
View Scheme
参考文献
McKew, John C.; Foley, Megan A.; Thakker, Paresh; Behnke, Mark L.; Lovering, Frank E.; Sum, Fuk-Wah; Tam, Steve; Wu, Kun; Shen, Marina W. H.; Zhang, Wen; Gonzalez, Mario; Liu, Shanghao; Mahadevan, Anu; Sard, Howard; Khor, Soo Peang; Clark, James D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 135 - 158
