4-苯基-1H-吡唑-3-羧酸乙酯合成路线 （共 8 条）
反应条件
pyrrolidine in dimethyl sulfoxide T=20°C; 24 h; regioselective reaction;
参考文献
Wang, Lei; Huang, Jiayao; Gong, Xiaojie; Wang, Jian
Chemistry - A European Journal, 2013 , vol. 19, # 23 p. 7555 - 7560
反应条件
in octane T=110°C; 1 h;
参考文献
Padwa, Albert; Kulkarni, Yashwant S.; Zhang, Zhijia
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4144 - 4153
反应条件
in tetrahydrofuran T=20°C; 96 h;
参考文献
Xie, Jian-Wu; Wang, Zheng; Yang, Wei-Jun; Kong, Li-Chun; Xu, Dong-Cheng
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 21 p. 4352 - 4354
反应条件
1: 60 percent / POCl3, pyridine / 1) 0 deg C, 6 h, 2) r.t., 12 h 2: 61 percent / octane / 1 h / 110 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 13 p. 4144 - 4153
反应条件
1: 1) n-BuLi / 1) ether, THF, -110 deg C, 2) -110 to -25 deg C 2: 60 percent / POCl3, pyridine / 1) 0 deg C, 6 h, 2) r.t., 12 h 3: 61 percent / octane / 1 h / 110 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 13 p. 4144 - 4153
反应条件
1: 1.) NaH / 1.) dioxane, 50 deg C, 2.) dioxane, 50 deg C, overnight 2: aq. NaOH / ethanol 3: thionyl chloride / benzene / 2 h / Heating 4: hydroxyl amine hydrochloride, aq. NaOH / diethyl ether / 3 h View Scheme
参考文献
Nagarajan, Kuppuswamy; Shah, Rashmi K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1992 , vol. 31, # 6 p. 316 - 321
反应条件
potassium hydroxide in methanol 0.5 h; Heating;
参考文献
Faidallah; Makki; Elmassry; Hassan
Pharmazie, 1997 , vol. 52, # 2 p. 101 - 105
参考文献
Kohler, Steele
Journal of the American Chemical Society, 1919 , vol. 41, p. 1097
