1: With trifluoroacetic anhydride in toluene T=10 - 40°C; 73 h; 2: With sodium hydroxide in water; toluene T=20 - 35°C; pH=10; 1 h; 3: With AlCl3, aluminium chloride in toluene T=70°C; Friedel Crafts Acylation; 1 h;

pyridine hydrochloride Heating;

hydrogen bromide; acetic acid in acetic acid

1: K2CO3 / acetone / Heating 2: 1) NaH / 1) DMSO, 2) DMSO 30 deg C 3: 82.5 percent / HBr-CH3COOH / acetic acid View Scheme

1: 1) NaH / 1) DMSO, 2) DMSO 30 deg C 2: 82.5 percent / HBr-CH3COOH / acetic acid View Scheme

(i) NaOEt, EtOH, (ii) /BRN= 605280/, benzene; Multistep reaction;