(2E)-2-(羟基亚氨基)-n-(3-甲氧基苯基)乙酰胺合成路线 （共 7 条）
反应条件
1: 66 percent / polyphosphoric acid / 0.17 h / 80 °C 2: 78 percent / aq. NaOH, 30percent H2O2 / 24 h / Ambient temperature View Scheme
参考文献
Cooke; Haynes
Australian Journal of Chemistry, 1958 , vol. 11, p. 225,228
反应条件
1: 66 percent / polyphosphoric acid / 0.17 h / 80 °C 2: 78 percent / aq. NaOH, 30percent H2O2 / 24 h / Ambient temperature 3: 5 percent / BF3*MeOH / 18 h / Heating View Scheme
参考文献
Booker-Milburn, Kevin I.; Dunkin, Ian R.; Kelly, Frances C.; Khalaf, Abedawn I.; Learmonth, David A.; Proctor, George R.; Scopes, David I. C.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 21 p. 3261 - 3273
反应条件
PPA T=55 - 60°C; 6 h;
参考文献
Pavlidis; Perry
Synthetic Communications, 1994 , vol. 24, # 4 p. 533 - 548
反应条件
1: 66 percent / polyphosphoric acid / 0.17 h / 80 °C 2: 78 percent / aq. NaOH, 30percent H2O2 / 24 h / Ambient temperature 3: 52 percent / HCl / Heating View Scheme
参考文献
Booker-Milburn, Kevin I.; Dunkin, Ian R.; Kelly, Frances C.; Khalaf, Abedawn I.; Learmonth, David A.; Proctor, George R.; Scopes, David I. C.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 21 p. 3261 - 3273
参考文献
IDENIX PHARMACEUTICALS, INC.
Patent: WO2009/14730 A1, 2009 ;
Location in patent: Page/Page column 157-158 ;
WO 2009/014730 A1
反应条件
hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate in water
0.166667 h; Heating;
参考文献
Pavlidis; Perry
Synthetic Communications, 1994 , vol. 24, # 4 p. 533 - 548
参考文献
Yamagishi; Yamada; Ozaki; Asao; Shimizu; Suzuki; Matsumoto; Matsuoka
Journal of Medicinal Chemistry, 1992 , vol. 35, # 11 p. 2085 - 2094
