(S)-3-氨基-3-(3,4-二甲基苯基)-丙酸合成路线 （共 5 条）
反应条件
1: With sodium hydroxide; water in methanol T=20 - 25°C; 2.25 h; 2: With acetic acid in tetrahydrofuran T=20 - 25°C; 1.5 h;
参考文献
CELGENE CORPORATION
Patent: WO2004/45597 A1, 2004 ;
Location in patent: Page/Page column 35; 39 ;
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 15 h;
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 95 percent / tetrahydrofuran; hexane / 3 h / -78 °C 2.1: 85 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr 3.1: 97 percent / trifluoroacetic acid / CH2Cl2 / 15 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 13 p. 1554 - 1566
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 95 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: 95 percent / tetrahydrofuran; hexane / 3 h / -78 °C 3.1: 85 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr 4.1: 97 percent / trifluoroacetic acid / CH2Cl2 / 15 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 13 p. 1554 - 1566
反应条件
1: 85 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr 2: 97 percent / trifluoroacetic acid / CH2Cl2 / 15 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 13 p. 1554 - 1566
