1: 88.5 percent / NMe3*HCl, POCl3 / 12 h / Heating 2: 74.6 percent / CH3COOK, H2 / 10percent Pd/C / methanol / 24 h / 760 Torr / Ambient temperature 3: 80.7 percent / CH3COOH, 30 percent H2O2 / 1.) 1 h at 40, 50, 60, 70, 80 and 90 deg C; 2.) 17 h, 100 deg C 4: 89.2 percent / 3 h / 140 °C View Scheme

T=255°C; 0.5 h;

1: 64.8 percent / acetic anhydride / 0.67 h / 100 - 110 °C 2: 88.8 percent / aq. NaOH / 1.5 h / Heating 3: 82.8 percent / 0.5 h / 255 °C View Scheme

1: 88.8 percent / aq. NaOH / 1.5 h / Heating 2: 82.8 percent / 0.5 h / 255 °C View Scheme

Yield given. Multistep reaction. Yields of byproduct given;

1: 88.5 percent / NMe3*HCl, POCl3 / 12 h / Heating 2: 74.6 percent / CH3COOK, H2 / 10percent Pd/C / methanol / 24 h / 760 Torr / Ambient temperature View Scheme

1: 88.5 percent / NMe3*HCl, POCl3 / 12 h / Heating 2: 74.6 percent / CH3COOK, H2 / 10percent Pd/C / methanol / 24 h / 760 Torr / Ambient temperature 3: 80.7 percent / CH3COOH, 30 percent H2O2 / 1.) 1 h at 40, 50, 60, 70, 80 and 90 deg C; 2.) 17 h, 100 deg C View Scheme