2-乙基-3,3-二甲基-丁酸合成路线 （共 7 条）
反应条件
potassium tert-butylate in dimethyl sulfoxide
参考文献
Lion, Claude; Dubois, Jacques-Emile
Journal of Chemical Research, Miniprint, 1980 , # 2 p. 565 - 576
反应条件
1: dilithiated tert-butylacetic acid With N,N'-dimethyl-N,N'-propyleneurea in tetrahydrofuran
T=5°C; 0.5 h;
2: ethyl iodide in tetrahydrofuran
T=20°C; 2 h;
参考文献
Kaufmann, Dan; Bialer, Meir; Shimshoni, Jakob Avi; Devor, Marshall; Yagen, Boris
Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 7236 - 7248
参考文献
Mosher; Cox
Journal of the American Chemical Society, 1950 , vol. 72, p. 3701,3703
反应条件
NOBF4 in acetonitrile
参考文献
Olah,G.A.; Olah,J.A.
Journal of Organic Chemistry, 1965 , vol. 30, p. 2386 - 2387
反应条件
1: t-butyl acetic acid With lithium diisopropyl amide in tetrahydrofuran
T=-15 - -5°C; Inert atmosphere;
2: With N,N'-dimethyl-N,N'-propyleneurea in tetrahydrofuran
T=5°C; 0.5 h;
3: ethyl iodide in tetrahydrofuran
T=20°C; 2 h;
参考文献
Hen, Naama; Bialer, Meir; Wlodarczyk, Bogdan; Finnell, Richard H.; Yagen, Boris
Journal of Medicinal Chemistry, 2010 , vol. 53, # 10 p. 4177 - 4186
反应条件
potassium hydroxide; potassium acetate
T=370°C; unter Ruehren;
参考文献
Dow Chem.Co.
Patent: US2531363 , 1949 ;
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Sarel; Newman
Journal of the American Chemical Society, 1956 , vol. 78, p. 5416,5418
