6-氟-苯并二氢吡喃-4-酮海因合成路线 （共 27 条）
反应条件
hydrogen bromide; acetic acid in water T=120 - 130°C; 2 h;
参考文献
Journal of Organic Chemistry, , vol. 47, # 21 p. 4081 - 4085
反应条件
1: 36 percent / α-chymotrypsin / H2O; aq. HCl; NaCl / 60 h / 20 °C 2: 61 percent / acetic acid / 1.) RT, 24 h; 2.) 90 deg C, 3 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 16 p. 3587 - 3591
反应条件
in water; acetic acid; ethyl acetate
反应条件
1: 64 percent / (NH4)2CO3 / H2O; ethanol / 63 h / 65 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 11 p. 1716 - 1720
反应条件
hydrogenchloride 1.) water, 1 m phosphate buffer pH 7.7, 50 deg C, 4 h, 2.) water, reflux, 1h; Yield given. Multistep reaction;
参考文献
European Journal of Medicinal Chemistry, , vol. 22, p. 559 - 568
反应条件
1: 82 percent / ethanol / 1.42 h / -10 - 0 °C 2: 2.) 1N HCl / 1.) CH2Cl2, RT, 20 min, 2.) steam bath, 1.5 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 21 p. 4081 - 4085
反应条件
in acetic acid 1.) RT, 24 h; 2.) 90 deg C, 3 h;
参考文献
Journal of Organic Chemistry, , vol. 52, # 16 p. 3587 - 3591
反应条件
1: 81 percent / 40percent N-benzyltrimethylammonium hydroxide in methanol (Triton B) / 39 h / Heating 2: 84 percent / HCl, 97percent HCO2H / 4 h / Heating 3: 83 percent / polyphosphoric acid / 0.33 h / Heating 4: 64 percent / (NH4)2CO3 / H2O; ethanol / 63 h / 65 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 11 p. 1716 - 1720
反应条件
1: 83 percent / polyphosphoric acid / 0.33 h / Heating 2: 64 percent / (NH4)2CO3 / H2O; ethanol / 63 h / 65 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 11 p. 1716 - 1720
反应条件
1: 84 percent / HCl, 97percent HCO2H / 4 h / Heating 2: 83 percent / polyphosphoric acid / 0.33 h / Heating 3: 64 percent / (NH4)2CO3 / H2O; ethanol / 63 h / 65 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 11 p. 1716 - 1720
