6-氟-苯并二氢吡喃-4-酮海因合成路线 （共 27 条）
反应条件
1: 2.) 1N HCl / 1.) CH2Cl2, RT, 20 min, 2.) steam bath, 1.5 h 2: 1N HCl / 2 h / 100 °C 3: 50 percent / 48percent HBr, glacial acetic acid / H2O / 2 h / 120 - 130 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 21 p. 4081 - 4085
反应条件
1: methanesulfonic acid / 18 h / Ambient temperature 2: acetic anhydride / dimethylformamide / 20 °C / 1.) 20 deg C, 2.) 50 deg C 3: 3 N NaOH / H2O / 2 h / Heating 4: 88 percent / formic acid, concd. HCl / H2O / 6 h / Heating 5: 73 percent / thionyl chloride / methanol 6: 36 percent / α-chymotrypsin / H2O; aq. HCl; NaCl / 60 h / 20 °C 7: 61 percent / acetic acid / 1.) RT, 24 h; 2.) 90 deg C, 3 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 16 p. 3587 - 3591
反应条件
1: 3 N NaOH / H2O / 2 h / Heating 2: 88 percent / formic acid, concd. HCl / H2O / 6 h / Heating 3: 73 percent / thionyl chloride / methanol 4: 36 percent / α-chymotrypsin / H2O; aq. HCl; NaCl / 60 h / 20 °C 5: 61 percent / acetic acid / 1.) RT, 24 h; 2.) 90 deg C, 3 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 16 p. 3587 - 3591
反应条件
1: 88 percent / formic acid, concd. HCl / H2O / 6 h / Heating 2: 73 percent / thionyl chloride / methanol 3: 36 percent / α-chymotrypsin / H2O; aq. HCl; NaCl / 60 h / 20 °C 4: 61 percent / acetic acid / 1.) RT, 24 h; 2.) 90 deg C, 3 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 16 p. 3587 - 3591
反应条件
1: acetic anhydride / dimethylformamide / 20 °C / 1.) 20 deg C, 2.) 50 deg C 2: 3 N NaOH / H2O / 2 h / Heating 3: 88 percent / formic acid, concd. HCl / H2O / 6 h / Heating 4: 73 percent / thionyl chloride / methanol 5: 36 percent / α-chymotrypsin / H2O; aq. HCl; NaCl / 60 h / 20 °C 6: 61 percent / acetic acid / 1.) RT, 24 h; 2.) 90 deg C, 3 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 16 p. 3587 - 3591
反应条件
1: 73 percent / thionyl chloride / methanol 2: 36 percent / α-chymotrypsin / H2O; aq. HCl; NaCl / 60 h / 20 °C 3: 61 percent / acetic acid / 1.) RT, 24 h; 2.) 90 deg C, 3 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 16 p. 3587 - 3591
反应条件
1: 1N HCl / 2 h / 100 °C 2: 50 percent / 48percent HBr, glacial acetic acid / H2O / 2 h / 120 - 130 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 21 p. 4081 - 4085
反应条件
in di-isopropyl ether; water; acetone T=25°C; 5 h; lipase from Pseudomonas sp.; Yield given;
参考文献
Tetrahedron Asymmetry, , vol. 5, # 8 p. 1407 - 1410
反应条件
1.1: 86 percent / conc. HCl / 16 h / Heating 2.1: H2O / 14 h / 80 °C 2.2: conc. HCl / 8 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 15 p. 3147 - 3151
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 11 p. 1716 - 1720
