(Z)-2-[2-(三苯甲基氨基)噻唑-4-基]-2-(三苯甲基氧基亚氨基)乙酸乙酯合成路线 （共 4 条）
反应条件
1: 97.6 percent / aq. NaOH / dioxane / 2 h / 100 - 110 °C 2: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C 3: TFA; anisole / CH2Cl2 / 0 - 5 °C 4: 2.54 g / aq. HCOOH / 3 h / 20 °C View Scheme
参考文献
Gonzalez, Maritza; Rodriguez, Zalua; Tolon, Blanca; Rodriguez, Juan C.; Velez, Herman; Valdes, Barbara; Lopez, Miguel A.; Fini, Adamo
Farmaco, 2003 , vol. 58, # 6 p. 409 - 418
反应条件
water; sodium hydroxide in 1,4-dioxane
T=100°C;
参考文献
ACHAOGEN, INC.; WAGMAN, Allan, Scott; MOSER, Heinz, Ernst
Patent: WO2010/30811 A2, 2010 ;
Location in patent: Page/Page column 94 ;
WO 2010/030811 A2
反应条件
Multi-step reaction with 2 steps 1: 97.6 percent / aq. NaOH / dioxane / 2 h / 100 - 110 °C2: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C
参考文献
Gonzalez, Maritza; Rodriguez, Zalua; Tolon, Blanca; Rodriguez, Juan C.; Velez, Herman; Valdes, Barbara; Lopez, Miguel A.; Fini, Adamo Farmaco, 2003 , vol. 58, # 6 p. 409 - 418
反应条件
Multi-step reaction with 3 steps 1: 97.6 percent / aq. NaOH / dioxane / 2 h / 100 - 110 °C2: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C3: TFA; anisole / CH2Cl2 / 0 - 5 °C
参考文献
Gonzalez, Maritza; Rodriguez, Zalua; Tolon, Blanca; Rodriguez, Juan C.; Velez, Herman; Valdes, Barbara; Lopez, Miguel A.; Fini, Adamo Farmaco, 2003 , vol. 58, # 6 p. 409 - 418
