2-甲基-2,4-己二烯酸甲酯合成路线 （共 4 条）
反应条件
potassium carbonate in acetone
T=20°C;
参考文献
CONCERT PHARMACEUTICALS INC.
Patent: WO2008/79383 A1, 2008 ;
Location in patent: Page/Page column 34-35 ;
反应条件
in diethyl ether
Yield given;
参考文献
Wakita, Hisanori; Matsumoto, Kazuhisa; Yoshiwara, Hideo; Hosono, Yutaka; Hayashi, Ryoji; Nishiyama, Hisao; Nagase, Hiroshi
Tetrahedron, 1999 , vol. 55, # 9 p. 2449 - 2474
反应条件
(i) LDA, HMPT, (ii) /BRN= 605306/, (iii) /BRN= 1098229/, H2SO4; Multistep reaction;
参考文献
Schering
Patent: DE2729960 , 1979 ;
Chem.Abstr., 1979 , vol. 90, # 151671
反应条件
1: methanephosphonic acid dimethyl ester With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: methyl 2-methyl-4-hexynate in tetrahydrofuran; hexane
T=-78 - 20°C; 4 h;
参考文献
CONCERT PHARMACEUTICALS, INC.; MASSE, Craig E.; HARBESON, Scott, L.; TUNG, Roger, D.
Patent: WO2011/3058 A1, 2011 ;
Location in patent: Page/Page column 64 ;
