4-溴-2,6-二甲基嘧啶合成路线 （共 4 条）
反应条件
sodium carbonate; toluene-4-sulfonic acid hydrazide
1.) CHCl3, reflux, 12 h, 2.) reflux, 30 min;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi
Synthesis, 1984 , # 3 p. 252 - 254
反应条件
1.1: trichlorophosphate / 3 h / 110 °C
2.1: toluene-4-sulfonic acid hydrazide / chloroform / 16 h / 90 °C
2.2: 1.5 h / 90 °C
View Scheme
参考文献
GLAXOSMITHKLINE LLC; BROWN, Kristin, K.; CHAI, Deping; DODSON, Christopher, S.; DUFFY, Kevin, J.; SHAW, Antony, Nicholas
Patent: WO2013/96151 A1, 2013 ;
反应条件
1.1: bromine / 1,4-dioxane / 0.75 h / 20 °C
2.1: trichlorophosphate / 3 h / 110 °C
3.1: toluene-4-sulfonic acid hydrazide / chloroform / 16 h / 90 °C
3.2: 1.5 h / 90 °C
View Scheme
参考文献
GLAXOSMITHKLINE LLC; BROWN, Kristin, K.; CHAI, Deping; DODSON, Christopher, S.; DUFFY, Kevin, J.; SHAW, Antony, Nicholas
Patent: WO2013/96151 A1, 2013 ;
反应条件
1: 85 percent / bis<triphenylphosphine>palladium dichloride, copper(I) iodide, triethylamine / 6 h / 100 °C
2: 77 percent / aq. KOH / methanol / 1 h / Ambient temperature
View Scheme
参考文献
Sakamoto, Takao; Shiraiwa, Masafumi; Kondo, Yoshinori; Yamanaka, Hiroshi
Synthesis, 1983 , # 4 p. 312 - 314
