2,3,5-三甲基苯酚合成路线 （共 124 条）
反应条件
hydrogenchloride; sodium hydroxide; sodium nitrite in water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5376681 A1, 1994 ;
反应条件
sodium hydroxide; 4-sulfo-benzenediazonium-(1)-salt beim Erwaermen des Reaktionsgemisches mit Natriumdithionit in Wasser;
参考文献
Smith; Irwin
Journal of the American Chemical Society, 1941 , vol. 63, p. 1036,1040
反应条件
1: 61 percent / KOH / 0.5 h / Heating 2: 1.) POCl3 / 1.) 0 deg C, 2 h, 2.) 70 deg, 24 h 3: 93 percent / LiAlH4 View Scheme
参考文献
Bestmann; Ermann
1984 , vol. 1984, # 10 p. 1740 - 1745
反应条件
potassium hydroxide; sodium acetate; trichlorophosphate in N-methyl-acetamide; ethanol; water; benzene
参考文献
Hoffmann-La Roche Inc.
Patent: US4021574 A1, 1977 ;
反应条件
1.1: 90 percent / NaH / dimethylsulfoxide; various solvent(s) / 12 h / 30 - 40 °C 2.1: POCl3 / 1 h 2.2: 63 percent / 24.5 h / 0 - 20 °C View Scheme
参考文献
Bestmann; Ermann
1984 , vol. 1984, # 10 p. 1740 - 1745
反应条件
1: 72 percent / base 2: 95 percent / SnCl4 3: 100 percent View Scheme
参考文献
Lewin; Black; Bos; Goehring; Nair; Whiting; Bouquin; Tetrault; Carroll
Pharmaceutical Research, 1995 , vol. 12, # 7 p. 983 - 992
反应条件
diethylzinc in toluene 1.5 h; Heating;
参考文献
Lehnert, Erich K.; Sawyer, J. Scott; Macdonald, Timothy L.
Tetrahedron Letters, 1989 , vol. 30, # 39 p. 5215 - 5218
反应条件
2: copper oxide-chromium oxide; dioxane / 165 °C / 73550.8 Torr / Hydrogenolyse View Scheme
参考文献
Moss, Robert A.; Wang, Lei; Odorisio, Christina M.; Krogh-Jespersen, Karsten
Tetrahedron Letters, 2010 , vol. 51, # 11 p. 1467 - 1470
反应条件
trifluorormethanesulfonic acid in toluene T=110°C; 1 h;
参考文献
Tetrahedron, , vol. 60, # 12 p. 2843 - 2849
反应条件
1: 99.8 percent / 60percent NaH in oil / dimethylsulfoxide / 10 h / Ambient temperature 2: 72.5 percent / chlorosulfonic acid / CH2Cl2 / -10 - -5 °C 3: 1.) 4 N NaOH / 1.) acetone, 3 h, 2.) ethyl acetate 4: 1.) 0.2 N H2SO4, 2.) hydrogen / 2.) palladium black / 1.) ethyl acetate, 2.) methanol View Scheme
参考文献
Fujino, Masahiko; Wakimasu, Mitsuhiro; Kitada, Chieko
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2825 - 2831
