4’,5’-二甲基-2’-硝基乙酰苯胺合成路线 （共 15 条）
反应条件
hydrogenchloride T=100°C;
参考文献
Maslennikova, T. A.; Shaburov, V. V.; El'tsov, A. V.
J. Gen. Chem. USSR (Engl. Transl.), 1981 , vol. 51, # 1 p. 134 - 146,119 - 128
反应条件
1: aq. NaOH solution 2: NaNO2; aqueous H2SO4 / anschliessend Behandeln mit wss. Kaliumthiocyanat 3: aqueous Na2SO3 4: zinc-powder; acetic acid / folgendes Erhitzen mit Acetanhydrid View Scheme
参考文献
Lewkoew et al.
Zhurnal Obshchei Khimii, 1952 , vol. 22, p. 516,518; engl. Ausg. S. 581, 584
反应条件
1: iron; acetic acid
2: aqueous acetic acid; NaNO2
View Scheme
参考文献
Benson et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 4917,4919
反应条件
1: picric acid; boric acid; iron (II)-sulfate / und konz. Schwefelsaeure
2: SnCl2; aqueous HCl
View Scheme
参考文献
Manske et al.
Canadian Journal of Research, Section B: Chemical Sciences, 1942 , vol. 20, p. 133,135
反应条件
1: conc. sulfuric acid / 0.25 h / 100 °C
2: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min
3: toluene / 2 h / Heating
View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
