6-氯-1,3-二甲基脲嘧啶合成路线 （共 66 条）
反应条件
1: nitric acid / sulfuric acid / 2 h / 10 °C 2: dichloromethane; chloroform; water / 1 h / 20 °C / Inert atmosphere View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/114184 A1, 2011 ;
WO 2011/114184 A1
反应条件
1: 85 percent / triethylamine / methanol / 5 h / Heating 2: 86 percent / isopentyl nitrite / toluene / 0.08 h / Heating 3: 91 percent / toluene / 6 h / Heating View Scheme
参考文献
Matsumoto, Nobuaki; Takahashi, Masahiko
Tetrahedron, 2002 , vol. 58, # 50 p. 10073 - 10079
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in dichloromethane; water 2.5 h; Ambient temperature;
参考文献
Gogoi, Mukti; Sandhu, Jagir S.; Baruah, J. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 9 p. 851 - 852
反应条件
(i) EtOH, (ii) isopentylnitrite, HCl, (iii) (heating); Multistep reaction;
参考文献
Goldner,H. et al.
Justus Liebigs Annalen der Chemie, 1966 , vol. 692, p. 134 - 150
反应条件
1: triethylamine / propan-2-ol / 3 h / Heating 2: pyridine / 3 h / 0 °C 3: 1.) NaOH, 2.) p-toluenesulfonic acid monohydrate / 1.) methanol, 50 deg C, 2.) 80 deg C, 1 h View Scheme
参考文献
Katakami; Yokoyama; Miyamoto; Mori; Kawauchi; Nobori; San-nohe; Kaiho; Kamiya
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3325 - 3330
反应条件
1.1: sodium hydride / tetrahydrofuran / 3 h / Heating 1.2: 51 percent / tetrahydrofuran / 18 h / 20 °C 2.1: 42 percent / acetonitrile / 1 h / Heating View Scheme
参考文献
Norris, Peter; Shechter, Harold
Journal of Organic Chemistry, 1999 , vol. 64, # 20 p. 7290 - 7298
反应条件
sulfuric acid; potassium nitrate 1.) 15 min, 7 deg C, 2.) 30 min, 20 deg C;
参考文献
Kuz'menko, V. V.; Kuz'menko, T. A.; Aleksandrov, G. G.; Pozharskii, A. F.; Gulevskaya, A. V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 6 p. 690 - 697
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , vol. 23, # 6 p. 836 - 844
反应条件
1: 57 percent
2: 50 percent / CuCl2, PdCl2, O2 / dimethylformamide; H2O
View Scheme
参考文献
Itoh; Imini; Ogura; et al.
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 4 p. 1375 - 1379
反应条件
1.1: sodium hydride / tetrahydrofuran / 3 h / Heating
1.2: 51 percent / tetrahydrofuran / 18 h / 20 °C
2.1: 92 percent / Raney nickel / H2O; ethanol / 0.5 h / 20 °C
View Scheme
参考文献
Sajiki, Hironao; Iida, Yusuke; Ikawa, Kanoko; Sawama, Yoshinari; Monguchi, Yasunari; Kitade, Yukio; Maki, Yoshifumi; Inoue, Hideo; Hirota, Kosaku
Molecules, 2012 , vol. 17, # 6 p. 6519 - 6546
反应条件
Chlor; acetic anhydride in acetic acid
1.) Raumtemperatur, 10 min, 2.) 50 deg C, 30 min;
参考文献
Szilagyti; Wamhoff
Synthesis, 1981 , vol. No.9, p. 701 - 702
