6-氯-1,3-二甲基脲嘧啶合成路线 （共 66 条）
反应条件
1: 77 percent / 3 h / 170 °C
2: 1.) sodium nitrite, 2.) Zn, AcOH / 1.) AcOH, 25-30 deg C, 40 min, 2.) 100 deg C, 20 min
View Scheme
参考文献
Krasnov
Russian Journal of Organic Chemistry, 1998 , vol. 34, # 1 p. 115 - 119
参考文献
Pfleiderer; Ferch
Justus Liebigs Annalen der Chemie, 1958 , vol. 615, p. 52,55
参考文献
Itoh, Tsuneo; Imini, Toshihiko; Ogura, Haruo; Kawahara, Norio; Nakajima, Takako; et al.
Heterocycles, 1983 , vol. 20, # 11 p. 2177 - 2180
参考文献
Krasnov
Russian Journal of Organic Chemistry, 1998 , vol. 34, # 1 p. 115 - 119
反应条件
1: 85 percent / H2O / 0.5 h / 100 °C
2: HCl, propyl nitrite / methanol; ethanol / 0.5 h / 40 °C
3: ethyl acetate; methanol / 0.5 h / 85 °C
View Scheme
参考文献
Rybar, A.; Alfoeldi, J.; Smondrkova, I.
Monatshefte fuer Chemie, 1994 , vol. 125, # 5 p. 565 - 570
反应条件
1: nitric acid / sulfuric acid / 2 h / 10 °C
2: dichloromethane; chloroform; water / 1 h / 20 °C / Inert atmosphere
3: hydrogen / palladium 10 on activated carbon / methanol / 20 °C
4: tetrahydrofuran / 18 h / 20 °C / Inert atmosphere; Reflux
View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/114184 A1, 2011 ;
WO 2011/114184 A1
反应条件
1: 85 percent / triethylamine / methanol / 5 h / Heating
2: 72 percent / 1 h / Heating
3: 88 percent / acetonitrile / UV-irradiation
View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/114184 A1, 2011 ;
WO 2011/114184 A1
反应条件
1: 85 percent / triethylamine / methanol / 5 h / Heating
2: 75 percent / triethylamine / CH2Cl2 / 20 h / 20 °C
3: 78 percent / acetonitrile / UV-irradiation
View Scheme
参考文献
Matsumoto, Nobuaki; Takahashi, Masahiko
Tetrahedron, 2002 , vol. 58, # 50 p. 10073 - 10079
反应条件
1: 59 percent / acetone / Irradiation
2: H2 / Pd-C
View Scheme
参考文献
Kaneko, Chikara; Shimomura, Naoyuki
Tetrahedron Letters, 1982 , vol. 23, # 25 p. 2571 - 2574
参考文献
Itoh; Imini; Ogura; et al.
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 4 p. 1375 - 1379
