6-氯-1,3-二甲基脲嘧啶合成路线 （共 66 条）
反应条件
1: 45 percent
2: 25 percent / CuCl2, PdCl2, O2 / dimethylformamide; H2O
View Scheme
参考文献
Kawahara; Nakajima; Itoh; Ogura
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 4740 - 4748
反应条件
1: 63 percent / sodium carbonate / ethanol / 12 h / Heating
2: 71 percent / formic acid / 1 h / Heating
3: 65 percent / pyridinium chloride / 0.33 h / 210 °C
View Scheme
参考文献
Bernier, Jean-Luc; Henichart, Jean-Pierre
Journal of Organic Chemistry, 1981 , vol. 46, # 21 p. 4197 - 4198
反应条件
1: 63 percent / sodium carbonate / ethanol / 12 h / Heating
2: 71 percent / formic acid / 1 h / Heating
View Scheme
参考文献
Bernier, Jean-Luc; Henichart, Jean-Pierre
Journal of Organic Chemistry, 1981 , vol. 46, # 21 p. 4197 - 4198
反应条件
hydroxylamine hydrochloride; sodium ethanolate
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/114184 A1, 2011 ;
Location in patent: Page/Page column 48-49 ;
WO 2011/114184 A1
参考文献
Pfleiderer; Ferch
Justus Liebigs Annalen der Chemie, 1958 , vol. 615, p. 52,55
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether; water
Suzuki-Miyaura coupling; 16 h; Reflux;
参考文献
Shih, Yu-Chiao; Chien, Tun-Cheng
Tetrahedron, 2011 , vol. 67, # 21 p. 3915 - 3923
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether; water
Stille coupling; 16 h; Reflux;
参考文献
Shih, Yu-Chiao; Chien, Tun-Cheng
Tetrahedron, 2011 , vol. 67, # 21 p. 3915 - 3923
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether; water
Suzuki-Miyaura coupling; 16 h; Reflux;
参考文献
Shih, Yu-Chiao; Chien, Tun-Cheng
Tetrahedron, 2011 , vol. 67, # 21 p. 3915 - 3923
参考文献
Seki; Matsuda; Bando; Ohkura
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 12 p. 4737 - 4748
反应条件
trifluoroacetic acid
10 h; Ambient temperatureIrradiation;
参考文献
Ohkura; Kanazashi; Seki
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 2 p. 239 - 243
