4,5-二甲基-2-硝基苯胺合成路线 （共 37 条）
反应条件
1: With hydrogenchloride; tin(ll) chloride in ethanol; water T=20°C; 1 h; Inert atmosphereReflux; 2: With sodium hydrogencarbonate in ethanol; water T=20°C;
参考文献
UNIVERSITE DE LA MEDITERRANEE AIX-MARSEILLE II; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; CAMPLO, Michel; SIRI, Olivier; SEILLAN, Claire; IOVANNA, Juan; ANDRIEU, Claudia; MORIS, Marc Antoine; ROCCHI, Palma
Patent: WO2011/117830 A1, 2011 ;
Location in patent: Page/Page column 20 ;
反应条件
1: NBS / CCl4 2: (i) NaNO2, aq. H2SO4, EtOH, (ii) (heating) View Scheme
参考文献
Kleinschmidt; Braeuniger
Die Pharmazie, 1969 , vol. 24, # 2 p. 87 - 94
参考文献
Diepolder
Chemische Berichte, 1909 , vol. 42, p. 2922
反应条件
1: zinc; aqueous ethanolic NaOH 2: water View Scheme
参考文献
Dellweg et al.
Biochemische Zeitschrift, 1956 , vol. 327, p. 422,447
反应条件
10 Pd/C; hydrogen; acetic acid in methanol T=20°C; P=760.051 Torr;
参考文献
Liu, Zheng; Li, Haihong; Zhao, Qingjie; Shen, Jingshan
Heterocycles, 2008 , vol. 75, # 8 p. 1907 - 1911
反应条件
1: NaNO2; aqueous H2SO4 / anschliessend Behandeln mit wss. Kaliumthiocyanat 2: aqueous Na2SO3 3: zinc-powder; acetic acid / folgendes Erhitzen mit Acetanhydrid View Scheme
参考文献
Lewkoew et al.
Zhurnal Obshchei Khimii, 1952 , vol. 22, p. 516,518; engl. Ausg. S. 581, 584
反应条件
acetic acid Acetylation; 1 h; Heating;
参考文献
Kojima, Hirotatsu; Nakatsubo, Naoki; Kikuchi, Kazuya; Kawahara, Shigenori; Kirino, Yutaka; Nagoshi, Hiroshi; Hirata, Yasunobu; Nagano, Tetsuo
Analytical Chemistry, 1998 , vol. 70, # 13 p. 2446 - 2453
反应条件
1: 2-nitro-4,5-dimethylaniline With 5 palladium on charcoal; ammonium formate in toluene T=120°C; 1 h; 2: 2-nitro-benzaldehyde in toluene T=4 - 20°C; 16 h;
参考文献
Weires, Nicholas A.; Boster, Jared; Magolan, Jakob
European Journal of Organic Chemistry, 2012 , # 33 p. 6508 - 6512
反应条件
1: H2 / methanol / 2 h / 20 °C / 1551.49 Torr 2: 87 percent / oxone (R) / dimethylformamide / 2 h / 20 °C View Scheme
参考文献
Saha, Biswajit; Sharma, Sunil; Kundu, Bijoy
Synthetic Communications, 2007 , vol. 37, # 19 p. 3455 - 3470
反应条件
1: aqueous HCl / Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl 2: iron; aqueous acetic acid View Scheme
参考文献
Hinkel; Ayling; Walters
Journal of the Chemical Society, 1934 , p. 283,287, 1948
