4,5-二甲基-2-硝基苯胺合成路线 （共 37 条）
反应条件
1: (i) NaNO2, aq. HCl, (ii) /BRN= 3587243/, CuCN, aq. Na2CO3, toluene
2: aq. H2SO4
View Scheme
参考文献
Braendstroem,A.; Carlsson,A.I.
Acta Chemica Scandinavica (1947-1973), 1967 , vol. 21, p. 983 - 992
反应条件
1: H2 / Pd/C / ethanol / 12 h / 20 °C / 3750.3 Torr
2: 0.88 g / acetic acid; ethanol / 12 h / Heating
View Scheme
参考文献
Helissey, Philippe; Desbene-Finck, Stephanie; Giorgi-Renault, Sylviane
European Journal of Organic Chemistry, 2005 , # 2 p. 410 - 415
反应条件
1: With hydrogen bromide
T=70°C; 0.5 h;
2: With sodium nitrite
T=-5°C; 0.25 h;
3: With hydrogen bromide; copper(I) bromide
T=-5 - 70°C; 0.25 h;
参考文献
Langner, Martin; Remy, Pauline; Bolm, Carsten
Chemistry - A European Journal, 2005 , vol. 11, # 21 p. 6254 - 6265
反应条件
sodium bromide; hydrogen bromide; sodium sulfite; sodium nitrite in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid; water; acetic acid
参考文献
Schering Aktiengesellschaft
Patent: US4411910 A1, 1983 ;
反应条件
dihydrogen peroxide in water; acetic acid
T=45 - 55°C; 16 h;
参考文献
Svoboda, Jiri; Schmaderer, Harald; Koenig, Burkhard
Chemistry - A European Journal, 2008 , vol. 14, # 6 p. 1854 - 1865
反应条件
potassium hydroxide; sodium hypochlorite in quinoline; ethanol; water
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
hydrogenchloride
Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl;
参考文献
Adams; Weisel; Mosher
Journal of the American Chemical Society, 1946 , vol. 68, p. 883,886
Full Text Show Details
Hinkel; Ayling; Walters
Journal of the Chemical Society, 1934 , p. 283,287, 1948
