2-(4-硝基苯基)丁酸乙酯合成路线 （共 13 条）
反应条件
1: 1) NaH / 1) DMF, 0 deg C, 60 min, 2) DMF, 0 deg C, 0.5 h 2: 60 percent / polyphosphoric acid / 0.5 h / 180 °C 3: 90 percent / H2 / Pd/C / methanol / 5 h / Ambient temperature View Scheme
参考文献
Bushell, Simon M.; Crump, J. Paul; Lawrence, Nicholas J.; Pineau, Guillaume
Tetrahedron, 1998 , vol. 54, # 10 p. 2269 - 2274
反应条件
sulfuric acid in ethanol
参考文献
Mitsubishi Chemical Industries Ltd.; Nippon Shinyaku Co., Ltd.
Patent: US4439448 A1, 1984 ;
反应条件
palladium on charcoal in N-methyl-acetamide; hydrogenchloride; ethanol; water; toluene; mineral oil
参考文献
Ciba-Geigy Corporation
Patent: US4316850 A1, 1982 ;
反应条件
sodium hydride in N,N-dimethyl-formamide
T=0°C; 2.5 h;
参考文献
Bushell, Simon M.; Crump, J. Paul; Lawrence, Nicholas J.; Pineau, Guillaume
Tetrahedron, 1998 , vol. 54, # 10 p. 2269 - 2274
反应条件
sodium hydride in N,N-dimethyl-formamide
T=0°C; 2 h;
参考文献
Bushell, Simon M.; Crump, J. Paul; Lawrence, Nicholas J.; Pineau, Guillaume
Tetrahedron, 1998 , vol. 54, # 10 p. 2269 - 2274
反应条件
sodium hydride in N,N-dimethyl-formamide
T=0°C; 2 h;
参考文献
Bushell, Simon M.; Crump, J. Paul; Lawrence, Nicholas J.; Pineau, Guillaume
Tetrahedron, 1998 , vol. 54, # 10 p. 2269 - 2274
反应条件
sulfuric acid; nitric acid
2 h;
参考文献
Hamacher; Bormann
Archiv der Pharmazie, 1981 , vol. 314, # 3 p. 257 - 267
参考文献
Wilds; Biggerstaff
Journal of the American Chemical Society, 1945 , vol. 67, p. 789,791
反应条件
1: 88 percent / DBU / toluene / 18 h / Ambient temperature
2: 55 percent / NaH / dimethylformamide / 2 h / 0 °C
View Scheme
参考文献
Bushell, Simon M.; Crump, J. Paul; Lawrence, Nicholas J.; Pineau, Guillaume
Tetrahedron, 1998 , vol. 54, # 10 p. 2269 - 2274
反应条件
1: 90 percent / conc. H2SO4 / 5 h / Heating
2: 91 percent / conc. H2SO4, HNO3 / 2 h
View Scheme
参考文献
Hamacher; Bormann
Archiv der Pharmazie, 1981 , vol. 314, # 3 p. 257 - 267
