1-乙酰基-2,3,5-三苯甲酰氧基-1-beta-D-呋喃核糖合成路线 （共 164 条）
反应条件
1: N,O-bis(trimethylsilyl)acetamide; trimethylsilyl triflate / acetonitrile / 0.08 h / 130 °C / microwave irradiation 2: NH3 / methanol / 16 h / 50 °C View Scheme
参考文献
Bookser, Brett C.; Raffaele, Nicholas B.
Journal of Organic Chemistry, 2007 , vol. 72, # 1 p. 173 - 179
反应条件
1: With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate in acetonitrile T=130°C; Vorbrueggen glycosylation; 0.0833333 h; microwave irradiation; 2: With ammonia in methanol T=50°C; 16 h; Title compound not separated from byproducts;
参考文献
Bookser, Brett C.; Raffaele, Nicholas B.
Journal of Organic Chemistry, 2007 , vol. 72, # 1 p. 173 - 179
反应条件
1: 1.) hexamethyldisilazane, ammonium sulfate, 2.) Me3SiCl, CF3SO3Cl / 1.) acetonitrile, reflux, 2.) acetonitrile, reflux, 3 h 2: 80 percent / NH3 / methanol / 24 h / 4 °C View Scheme
参考文献
Manfredini, Stefano; Bazzanini, Rita; Baraldi, Pier Giovanni; Guarneri, Mario; Simoni, Daniele; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 917 - 924
反应条件
1: 1.) hexamethyldisilazane, ammonium sulfate, 2.) Me3SiCl, CF3SO3Cl / 1.) acetonitrile, reflux, 2.) acetonitrile, reflux, 3 h 2: 80 percent / NH3 / methanol / 24 h / 4 °C View Scheme
参考文献
Manfredini, Stefano; Bazzanini, Rita; Baraldi, Pier Giovanni; Guarneri, Mario; Simoni, Daniele; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 917 - 924
反应条件
1: 1.) hexamethyldisilazane, ammonium sulfate, 2.) Me3SiCl, CF3SO3Cl / 1.) acetonitrile, reflux, 2.) acetonitrile, reflux, 3 h 2: 80 percent / NH3 / methanol / 24 h / 4 °C View Scheme
参考文献
Manfredini, Stefano; Bazzanini, Rita; Baraldi, Pier Giovanni; Guarneri, Mario; Simoni, Daniele; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 917 - 924
反应条件
1: trimethylsilyl triflate / acetonitrile / 0.5 h / Ambient temperature 2: MeONa/MeOH / 12 h / Ambient temperature 3: trifluoroacetic acid / 12 h / Ambient temperature View Scheme
参考文献
Felczak, Krzysztof; Drabikowska, Alicja K.; Vilpo, Juhani A.; Kulikowski, Tadeusz; Shugar, David
Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1720 - 1728
反应条件
1: 1.) hexamethyldisilazane, ammonium sulfate, 2.) Me3SiCl, CF3SO3Cl / 1.) acetonitrile, reflux, 2.) acetonitrile, reflux, 3 h 2: 82 percent / NH3 / methanol / 24 h / 4 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 5 p. 917 - 924
反应条件
1: With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate in acetonitrile T=130°C; Vorbrueggen glycosylation; 0.0833333 h; microwave irradiation; 2: With ammonia in methanol T=50°C; 16 h;
参考文献
Bookser, Brett C.; Raffaele, Nicholas B.
Journal of Organic Chemistry, 2007 , vol. 72, # 1 p. 173 - 179
反应条件
1: N,O-bis(trimethylsilyl)acetamide; trimethylsilyl triflate / acetonitrile / 0.08 h / 130 °C / microwave irradiation 2: NH3 / methanol / 16 h / 50 °C View Scheme
参考文献
Bookser, Brett C.; Raffaele, Nicholas B.
Journal of Organic Chemistry, 2007 , vol. 72, # 1 p. 173 - 179
反应条件
1: hydrogen chloride; diethyl ether 2: ueber mehrere Stufen 3: Raney nickel; ethanol View Scheme
参考文献
Bookser, Brett C.; Raffaele, Nicholas B.
Journal of Organic Chemistry, 2007 , vol. 72, # 1 p. 173 - 179
