1-乙酰基-2,3,5-三苯甲酰氧基-1-beta-D-呋喃核糖合成路线 （共 164 条）
反应条件
1: SnCl4 / acetonitrile / 4 h / Ambient temperature 2: NH3 / methanol / 42 h / Ambient temperature View Scheme
参考文献
Garner, Philip; Ramakanth, Sarabu
Journal of Organic Chemistry, 1988 , vol. 53, # 6 p. 1294 - 1298
反应条件
1: With trifluorormethanesulfonic acid in acetonitrile T=55°C; 12.5 h; Industry scale; 2: With methanol; sodium methylate in dimethyl sulfoxide; acetonitrile T=22 - 23°C; 3.75 h;
参考文献
ScinoPharm Taiwan Ltd.
Patent: US2010/36112 A1, 2010 ;
Location in patent: Page/Page column 7 ;
反应条件
tin(IV) chloride in dichloromethane; dimethyl sulfoxide
参考文献
US2014/135490 A1, ;
Page/Page column ;
反应条件
1: N,O-bis(trimethylsilyl)acetamide; trimethylsilyl triflate / acetonitrile / 0.08 h / 130 °C / microwave irradiation 2: NH3 / methanol / 16 h / 50 °C View Scheme
参考文献
Bookser, Brett C.; Raffaele, Nicholas B.
Journal of Organic Chemistry, 2007 , vol. 72, # 1 p. 173 - 179
反应条件
1: N,O-bis(trimethylsilyl)acetamide; trimethylsilyl triflate / acetonitrile / 0.08 h / 130 °C / microwave irradiation 2: NH3 / methanol / 16 h / 50 °C View Scheme
参考文献
Bookser, Brett C.; Raffaele, Nicholas B.
Journal of Organic Chemistry, 2007 , vol. 72, # 1 p. 173 - 179
反应条件
1: 93 percent / SnCl4 / 1,2-dichloro-ethane / 48 h / 20 °C 2: 80 percent / 1 N sodium methylate / methanol / 3 h / 20 °C 3: 1.) acetylsalicylic chloroanhydride, 2.) 0.5 N HCl / 1.) nitromethane, 20 deg C, 15 h, 2.) water, dioxane, 100 deg C, 2.5 h View Scheme
参考文献
Kvasyuk, E. I.; Kulak, T. I.; Tkachenko, O. V.; Mikhaylopulo, I. A.; Zinchenko, A. I.; et al.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 6 p. 493 - 496
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 6 p. 699 - 702
反应条件
1: With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate in acetonitrile T=130°C; Vorbrueggen glycosylation; 0.0833333 h; microwave irradiation; 2: With ammonia in methanol T=50°C; 16 h; Title compound not separated from byproducts;
参考文献
Bookser, Brett C.; Raffaele, Nicholas B.
Journal of Organic Chemistry, 2007 , vol. 72, # 1 p. 173 - 179
反应条件
1: 69 percent / stannic chloride / CH2Cl2 / 3 h / Heating 2: 71 percent / triethylamine / methanol / 2 h / 20 °C 3: 74 percent / bromotrichloromethane; 1,8-diazabicyclo[5.4.0]-undec-7-ene / CH2Cl2 / 16 h / 0 °C 4: 85 percent / NH3 / methanol / 24 h / 20 °C View Scheme
参考文献
Ramasamy, Kanda S.; Averett, Devron
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2425 - 2431
反应条件
1: With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate in acetonitrile T=130°C; Vorbrueggen glycosylation; 0.0833333 h; microwave irradiation; 2: With ammonia in methanol T=50°C; 16 h;
参考文献
Bookser, Brett C.; Raffaele, Nicholas B.
Journal of Organic Chemistry, 2007 , vol. 72, # 1 p. 173 - 179
反应条件
trimethylsilyl trifluoromethanesulfonate in 1,2-dichloro-ethane T=24°C; 0.5 h;
参考文献
Chemische Berichte, , vol. 114, # 4 p. 1234 - 1255
