alpha-甲基-1,3-苯并二氧代-5-乙醇合成路线 （共 14 条）
反应条件
Amano PS Lipase in hexane; benzene T=50°C; 72 h;
参考文献
Easwar, Srinivasan; Argade, Narshinha P.
Tetrahedron Asymmetry, 2003 , vol. 14, # 3 p. 333 - 337
反应条件
1: Dess-Martin periodane / dichloromethane / 20 °C / |Inert atmosphere; |Schlenk technique 2: nicotinamide adenine dinucleotide; magnesium chloride; alcohol dehydrogenase Evo-200; isopropyl alcohol / aq. phosphate buffer / 48 h / 30 °C / pH 7 / |Inert atmosphere; |Schlenk technique; |Enzymatic reaction View Scheme
参考文献
Simon, Robert C.; Busto, Eduardo; Richter, Nina; Belaj, Ferdinand; Kroutil, Wolfgang
European Journal of Organic Chemistry, 2014 , vol. 2014, # 1 p. 111 - 121
反应条件
Burkholderia cepacia lipase immobilized on ceramic particles T=20°C; 18 h; Title compound not separated from byproducts;
参考文献
Kiss, Violetta; Egri, Gabriella; Balint, Jozsef; Ling, Istvan; Barkoczi, Jozsef; Fogassy, Elemer
Tetrahedron Asymmetry, 2006 , vol. 17, # 15 p. 2220 - 2234
反应条件
Dess-Martin periodane in dichloromethane T=20°C; Dess-Martin Oxidation; Inert atmosphereSchlenk technique;
参考文献
Simon, Robert C.; Busto, Eduardo; Richter, Nina; Belaj, Ferdinand; Kroutil, Wolfgang
European Journal of Organic Chemistry, 2014 , vol. 2014, # 1 p. 111 - 121
反应条件
1: 94 percent / aq. HCl / dioxane / 1 h / Heating 2: 68 percent / H2 / 10 percent Pd/C / methanol / 4 h / 20 °C / atmospheric pressure 3: 65 percent / P2O5 / 1,2-dichloro-ethane / 12 h / 20 °C View Scheme
参考文献
Micale, Nicola; Zappala, Maria; Grasso, Silvana
Farmaco (Societa chimica italiana : 1989), 2002 , vol. 57, # 10 p. 853 - 859
反应条件
1: 75 percent / pyridinium chlorochromate / CH2Cl2 / 20 °C 2: 60 percent / P2O5 / 1,2-dichloro-ethane / 8 h / 20 °C 3: 50 percent / hydrazine hydrate / ethanol / 2 h / 20 °C 4: 80 percent / SnCl2 / ethanol / 1 h / 70 °C 5: 83 percent / NaBH3CN; HCl / methanol / 1 h / 20 °C View Scheme
参考文献
Zappala, Maria; Grasso, Silvana; Micale, Nicola; Polimeni, Santina; De Micheli, Carlo
Synthetic Communications, 2002 , vol. 32, # 4 p. 527 - 533
反应条件
hydrogen; palladium on activated charcoal in methanol
P=3361.5 Torr; 3 h;
参考文献
Barreiro, Eliezer J.; Costa, Paulo R. R.; Barros, Perola Regina V. R.; Queiroz, Waldemir M.
Journal of Chemical Research, Miniprint, 1982 , # 4 p. 1142 - 1165
反应条件
1: With mercury(II) diacetate in tetrahydrofuran
T=20°C; 1 h;
2: With sodium hydroxide; sodium tetrahydroborate in tetrahydrofuran
1 h;
参考文献
Zappala, Maria; Grasso, Silvana; Micale, Nicola; Polimeni, Santina; De Micheli, Carlo
Synthetic Communications, 2002 , vol. 32, # 4 p. 527 - 533
反应条件
1: 1,2-methylenedioxy-4-bromobenzene With n-butyllithium in diethyl ether; hexane
T=-78°C; 0.833333 h; Inert atmosphereSchlenk technique;
2: methyloxirane in diethyl ether; hexane
T=-78 - 20°C; 3 h; Inert atmosphereSchlenk technique;
参考文献
Simon, Robert C.; Busto, Eduardo; Richter, Nina; Belaj, Ferdinand; Kroutil, Wolfgang
European Journal of Organic Chemistry, 2014 , vol. 2014, # 1 p. 111 - 121
反应条件
sodium tetrahydroborate in methanol
16 h;
参考文献
Bhide, Bhaskar H.; Shah, Kashmira K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 1 p. 9 - 12
