1: 2,4-difluoro-5-iodobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in ethyl acetate T=20°C; 2 h; 2: ethyl-3,3-dimethylaminoacrylate With triethylamine in tetrahydrofuran 3 h; Heating / reflux; Product distribution / selectivity;

1: 2,4-difluoro-5-iodobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in toluene T=20°C; 12 h; 2: 3-(dimethylamino)acrylic acid ethyl ester With triethylamine in tetrahydrofuran; toluene 1 h; Heating / reflux; Product distribution / selectivity;

triethylamine in tetrahydrofuran 1 - 15 h; Heating / reflux; Product distribution / selectivity;

1.1: sulfuric acid / dichloromethane / 0.5 h / 0 - 5 °C 1.2: 5 °C 2.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 85 - 90 °C / Inert atmosphere 3.1: N-ethyl-N,N-diisopropylamine / toluene / 4.5 h / 90 - 95 °C View Scheme

1: in tetrahydrofuran T=20 - 50°C; 0.5 - 2 h; 2: With potassium carbonate in DMF (N,N-dimethyl-formamide) T=60 - 70°C; 1.5 - 2.5 h; Product distribution / selectivity;

in hexane; ethyl acetate Heating / reflux; Product distribution / selectivity;