4-(3-氟苯基)-4-氧代丁酸合成路线 （共 3 条）
反应条件
1: in tetrahydrofuran T=-78 - 20°C; 4 h; 2: With hydrogenchloride; water in tetrahydrofuran
参考文献
WO2007/62797 A1, ;
Page/Page column 25 ;
WO 2007/062797 A1
反应条件
1: 1.) 30 percent KOH / 1.) THF, EtOH, 18 h, 2.) H2O, acetic acid, reflux, 1 h 2: 6 N HCl / hexane / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 3 p. 381 - 392
反应条件
potassium carbonate in N,N-dimethyl acetamide
T=135°C; 16 h;
参考文献
McEvoy, Francis J.; Lai, Fong M.; Albright, J. Donald
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 381 - 392
