2-溴-N,N-二甲基苯胺合成路线 （共 26 条）
反应条件
n-butyllithium in hexane 3.25 h; Inert atmosphereCooling with ice;
参考文献
Chernichenko, Konstantin; Nieger, Martin; Leskelae, Markku; Repo, Timo
Dalton Transactions, 2012 , vol. 41, # 30 p. 9029 - 9032
反应条件
in tetrahydrofuran; hexane T=-78 - 0°C; 2 h;
参考文献
Ehn, Marcel; Vassilev, Nikolay Georgiev; Kasak, Peter; Horvath, Branislav; Filo, Juraj; Mereiter, Kurt; Rakovsky, Erik; Putala, Martin
Tetrahedron Asymmetry, 2013 , vol. 24, # 20 p. 1303 - 1311
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1.25 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - 20°C; 49 h; 3: With hydrogenchloride in tetrahydrofuran; hexane 0.333333 h; Further stages.;
参考文献
Colobert, Francoise; Valdivia, Victoria; Choppin, Sabine; Leroux, Frederic R.; Fernandez, Inmaculada; Alvarez, Eleuterio; Khiar, Noureddine
Organic Letters, 2009 , vol. 11, # 22 p. 5130 - 5133
反应条件
1: 2-Bromo-N,N-dimethylaniline With magnesium in tetrahydrofuran Heating; 2: 1-bromo-2-chloro-benzene in tetrahydrofuran T=60°C; 2.25 h; 3: chlorodi-tert-butylphosphine With copper(l) chloride in tetrahydrofuran T=60°C; 20 h; Further stages.;
参考文献
Kaye, Steven; Fox, Joseph M.; Hicks, Frederick A.; Buchwald, Stephen L.
Advanced Synthesis and Catalysis, 2001 , vol. 343, # 8 p. 789 - 794
反应条件
n-butyllithium 1.) Et2O, -40 deg C, 4 h, 2.) Et2O, r.t., overnight; Yield given. Multistep reaction;
参考文献
Kelly, David P.; Bateman, Stuart A.; Hook, Robert J.; Martin, Roger F.; Reum, Monica E.; et al.
Australian Journal of Chemistry, 1994 , vol. 47, # 9 p. 1751 - 1770
反应条件
tetrabutyl ammonium fluoride; palladium (II) bromide; biphenyl-2-yl-di-tert-butyl-phosphane in tetrahydrofuran T=50°C; 24 h; Title compound not separated from byproducts;
参考文献
Denmark, Scott E.; Butler, Christopher R.
Organic Letters, 2006 , vol. 8, # 1 p. 63 - 66
反应条件
1: With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=0°C; 2: With methanol in tetrahydrofuran Reactivity;
参考文献
Shi, Lei; Chu, Yuanyuan; Knoechel, Paul; Mayr, Herbert
Journal of Organic Chemistry, 2009 , vol. 74, # 7 p. 2760 - 2764
反应条件
1: With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=0°C; 2: With methanol in tetrahydrofuran Reactivity;
参考文献
Shi, Lei; Chu, Yuanyuan; Knoechel, Paul; Mayr, Herbert
Journal of Organic Chemistry, 2009 , vol. 74, # 7 p. 2760 - 2764
反应条件
Pd[P(o-tol)3]2; CyPF-t-Bu; ammonia; sodium t-butanolate in 1,4-dioxane T=80°C; 4 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 131, # 31 p. 11049 - 11061
反应条件
1: 2-Bromo-N,N-dimethylaniline With magnesium in tetrahydrofuran Heating; 2: 1-bromo-2-chloro-benzene in tetrahydrofuran T=60°C; 2.25 h; 3: chloro-dicyclohexylphosphine With copper(l) chloride in tetrahydrofuran; diethyl ether T=20°C; 1 h; Further stages.;
参考文献
Kaye, Steven; Fox, Joseph M.; Hicks, Frederick A.; Buchwald, Stephen L.
Advanced Synthesis and Catalysis, 2001 , vol. 343, # 8 p. 789 - 794
