2-溴-N,N-二甲基苯胺合成路线 （共 26 条）
反应条件
copper(l) iodide; potassium iodide; N-methyl-2-(methylamino)ethylamine in toluene T=130°C; Rosenmund-von Braun reaction; 24 h;
参考文献
Zanon, Jacopo; Klapars, Artis; Buchwald, Stephen L.
Journal of the American Chemical Society, 2003 , vol. 125, # 10 p. 2890 - 2891
反应条件
bromine; triphenylphosphine; zinc; palladium on activated charcoal in dimethyl amine T=115°C; 8 h;
参考文献
Hatsuda, Masanori; Seki, Masahiko
Tetrahedron, 2005 , vol. 61, # 41 p. 9908 - 9917
反应条件
n-butyllithium in tetrahydrofuran; diethyl ether; hexane
byproducts: LiBr; A soln. of o-C6H4Br(NMe2) in Et2O was added dropwise to n-BuLi in hexane at 0°C, after 1 h a soln. of SbCl3 in THF was added, the mixt. was refluxed for 30 min (N2 atm.);; hydrolysis the organic layer was sepd., dried and evapd., recrystd. from ethanol and acetone; elem. anal.;;
参考文献
Levason, William; Sheikh, Baharuddin
Journal of Organometallic Chemistry, 1981 , vol. 209, # 2 p. 161 - 168
反应条件
1: 2-Bromo-N,N-dimethylaniline With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 0°C; 0.75 h; Inert atmosphereSchlenk technique;
2: chloro-diphenylphosphine in tetrahydrofuran; hexane
T=-78 - 0°C; Inert atmosphereSchlenk technique;
参考文献
Richard, Vincent; Ipouck, Melinda; Merel, Delphine S.; Gaillard, Sylvain; Whitby, Richard J.; Witulski, Bernhard; Renaud, Jean-Luc
Chemical Communications, 2014 , vol. 50, # 5 p. 593 - 595
反应条件
1: With diisobutylaluminium hydride; magnesium; lithium chloride in tetrahydrofuran
T=0 - 25°C; Inert atmosphere;
2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in dichloromethane; perfluorodecahydronaphthalene
T=-78 - 25°C; Inert atmosphere;
参考文献
Yamada, Shigeyuki; Knochel, Paul
Synthesis, 2010 , # 14 art. no. T09010SS, p. 2490 - 2494
反应条件
tetrabutyl ammonium fluoride; palladium (II) bromide; biphenyl-2-yl-di-tert-butyl-phosphane in tetrahydrofuran
T=50°C; 24 h; Title compound not separated from byproducts;
参考文献
Denmark, Scott E.; Butler, Christopher R.
Organic Letters, 2006 , vol. 8, # 1 p. 63 - 66
