2-氯-N,N-二甲基苯胺合成路线 （共 26 条）
反应条件
1: N,N-dimethyl-2-chloroaniline With magnesium; ethylene dibromide in tetrahydrofuran Metallation; 48 h; Heating; 2: 1-bromo-2-chloro-benzene in tetrahydrofuran T=60°C; Arylation; 2 h; 3: chlorodi-tert-butylphosphine in tetrahydrofuran T=60°C; Substitution; 15 h; Further stages.;
参考文献
Tomori, Hiroshi; Fox, Joseph M.; Buchwald, Stephen L.
Journal of Organic Chemistry, 2000 , vol. 65, # 17 p. 5334 - 5341
反应条件
1: N,N-dimethyl-2-chloroaniline With magnesium; ethylene dibromide in tetrahydrofuran Metallation; 29.5 h; Heating; 2: 1-bromo-2-chloro-benzene in tetrahydrofuran T=60°C; Arylation; 2 h; 3: chloro-dicyclohexylphosphine With copper(l) chloride in tetrahydrofuran T=20°C; Substitution; 9 h; Further stages.;
参考文献
Tomori, Hiroshi; Fox, Joseph M.; Buchwald, Stephen L.
Journal of Organic Chemistry, 2000 , vol. 65, # 17 p. 5334 - 5341
反应条件
Multistep reaction.;
参考文献
Tomori, Hiroshi; Fox, Joseph M.; Buchwald, Stephen L.
Journal of Organic Chemistry, 2000 , vol. 65, # 17 p. 5334 - 5341
参考文献
van Duin
Recueil des Travaux Chimiques des Pays-Bas, 1932 , vol. 51, p. 878,879
反应条件
water; nitric acid; sodium nitrite
参考文献
van Duin
Recueil des Travaux Chimiques des Pays-Bas, 1932 , vol. 51, p. 878,879
参考文献
van Duin
Recueil des Travaux Chimiques des Pays-Bas, 1932 , vol. 51, p. 878,879
