2-甲基-4-氨基嘧啶-5-腈合成路线 （共 53 条）
反应条件
1: acetamidine hydrochloride With sodium methylate in methanol 0.166667 h; Cooling with ice; 2: α-Cyano-β-dimethylaminoacrylonitrile in methanol T=20°C; 12.5 h;
参考文献
CATABASIS PHARMACEUTICALS, INC.; MILNE, Jill C.; JIROUSEK, Michael R.; VU, Chi B.
Patent: WO2013/177536 A2, 2013 ;
Location in patent: Paragraph 0266 ;
反应条件
1: acetamidine hydrochloride With sodium methylate in ethanol T=20°C; 2: (ethoxymethylene)malononitrile in ethanol 1 h;
参考文献
Anderson, Kevin; Chen, Yi; Chen, Zhi; Luk, Kin-Chun; Rossman, Pamela Loreen; Sun, Hongmao; Wovkulich, Peter Michael
Patent: US2012/184542 A1, 2012 ;
Location in patent: Page/Page column 58 ;
US 20120184542 A1
反应条件
sodium methylate in methanol T=0°C; 0.333333 h;
参考文献
DSM IP ASSETS B.V.; FUDAN UNIVERSITY; CHEN, Fen-Er; ZHAO, Lei; XIONG, Fangjun
Patent: WO2012/75677 A1, 2012 ;
Location in patent: Page/Page column 6 ;
反应条件
sodium methylate in methanol T=20°C; 5 h; Inert atmosphere;
参考文献
WO2010/115950 A2, ;
Page/Page column 5 ;
反应条件
1: 1-Imino-ethanamine hydrochloride With sodium methylate in ethanol 0.583333 h; 2: 2,2-dicyanovinyl acetate in ethanol; dichloromethane T=0°C; 3.25 h;
参考文献
WO2011/116933 A1, ;
Page/Page column 5 ;
反应条件
1: 1-Imino-ethanamine hydrochloride With sodium methylate in methanol 0.166667 h; Cooling with iceLarge scale reaction; 2: α-Cyano-β-dimethylaminoacrylonitrile in methanol T=20°C; 12.5 h; CoolingLarge scale reaction;
参考文献
Zhao, Lei; Ma, Xiao-Dong; Chen, Fen-Er
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 57 - 60
反应条件
potassium carbonate; potassium hexacyanoferrate(III) in water
反应条件
dihydrogen peroxide; acetic acid in water
反应条件
acetic anhydride in 1,4-dioxane 14 h; Reflux;
参考文献
WO2011/116933 A1, ;
Page/Page column 5 ;
反应条件
in methanol T=20 - 25°C; 15.0833 h; Product distribution / selectivity;
参考文献
WO2011/60624 A1, ;
Page/Page column 6-7 ;
