7-氯-3H-咪唑[4,5-B]吡啶合成路线 （共 6 条）
反应条件
trichlorophosphate T=20 - 90°C; 18 h;
参考文献
WO2008/118468 A1, ;
Page/Page column 123 ;
反应条件
1: aq. H2O2; AcOH / 50 °C 2: POCl3 / 110 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 12 p. 3165 - 3168
反应条件
1: EtSO3H / 100 °C 2: aq. H2O2; AcOH / 50 °C 3: POCl3 / 110 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 12 p. 3165 - 3168
反应条件
trichlorophosphate 2 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Heterocyclic Chemistry, , vol. 19, # 3 p. 513 - 517
反应条件
phosphoric acid; hydrogen iodide in water T=55 - 70°C; 20 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; HUANG, Audris
Patent: WO2012/44537 A1, 2012 ;
Location in patent: Page/Page column 64-65 ;
WO 2012/044537 A1
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane
T=20°C; 0.5 h;
参考文献
SOLVAY PHARMACEUTICALS B.V.
Patent: US2006/52412 A1, 2006 ;
Location in patent: Page/Page column 4 ;
US 20060052412 A1
