4-(氯磺酰基)苯甲酸甲酯合成路线 （共 8 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran T=-78°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/66126 A1, 2005 ;
Location in patent: Page/Page column 73-74 ;
WO 2005/066126 A1
反应条件
1: 4-carboxybenzenesulfonyl chloride With thionyl chloride in dichloromethane 2 h; Reflux; 2: methanol 0.166667 h; Cooling with ice;
参考文献
ICAGEN, INC.; PFIZER LIMITED
Patent: WO2008/118758 A1, 2008 ;
Location in patent: Page/Page column 214 ;
WO 2008/118758 A1
反应条件
thionyl chloride in methanol; anhydrous dichloroethane; water
参考文献
Senomyx, Inc.
Patent: US2009/274632 A1, 2009 ;
反应条件
phenyl sulphuryl chloride; C43H43NO3PPdS; sodium carbonate in acetone T=60°C; 12 h; Inert atmosphereSealed tube;
参考文献
Debergh, J. Robb; Niljianskul, Nootaree; Buchwald, Stephen L.
Journal of the American Chemical Society, 2013 , vol. 135, # 29 p. 10638 - 10641
反应条件
in methanol T=20°C; 5 h;
参考文献
Li, Leping; Liu, Jiwen; Zhu, Liusheng; Cutler, Serena; Hasegawa, Hirohiko; Shan, Bei; Medina, Julio C.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1638 - 1642
反应条件
1.1: acetic anhydride; chromium(VI) oxide; acetic acid / 2 h / 20 - 40 °C 2.1: thionyl chloride / dichloromethane / 1 h / Reflux 2.2: 0.25 h / 20 °C / Cooling with ice bath View Scheme
参考文献
Magnetic Resonance in Chemistry, , vol. 27, # 6 p. 585 - 591
反应条件
1: 35 percent / zinc dust / ethanol / 6 h / 40 °C
2: 80 percent / thionyl chloride / 0.5 h / 40 °C
View Scheme
参考文献
Prosyanik, A.V.; Kol'tsov, N.Yu.; Romanchenko, V.A.; Belov, V.V.; Burmistrov, K.S.; Loban', S.V.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, p. 335 - 342
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 2 p. 375 - 382
