1,1'-bis-(diphenylphosphino)ferrocene; triethylamine; palladium diacetate in N,N-dimethyl-formamide T=60 - 70°C; 12 h;

1: 90 percent / 2,6-lutidine / CH2Cl2 / 0.5 h / 20 °C 2: 70 percent / dppf; Et3N / Pd(OAc)2 / dimethylformamide / 12 h / 60 - 70 °C View Scheme

1.1: S-BuLi; TMEDA / tetrahydrofuran / 1 h / -78 °C 1.2: B(OMe)3 / tetrahydrofuran / 20 °C 2.1: 2.51 g / MgSO4 / CH2Cl2 3.1: 60 percent / aq. Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / 12 h / Heating 4.1: 95 percent / LDA / tetrahydrofuran / 0.5 h / 20 °C 5.1: 95 percent / 2,6-lutidine / CH2Cl2 / 0.5 h / 20 °C 6.1: 92 percent / PPh3; Et3N; HCO2H / Pd(OAc)2 / dimethylformamide / 0.5 h / 70 °C View Scheme