2,4-二氯喹啉-3-甲腈合成路线 （共 10 条）
反应条件
palladium on activated charcoal; ethanol; sodium acetate Hydrogenation;
参考文献
Koller; Ruppersberg; Strang
Monatshefte fuer Chemie, 1929 , vol. 52, p. 60,67
参考文献
Koller; Ruppersberg; Strang
Monatshefte fuer Chemie, 1929 , vol. 52, p. 60,67
反应条件
phosphorus; hydrogen iodide
参考文献
Gabriel
Chemische Berichte, 1918 , vol. 51, p. 1509
反应条件
triethylamine; trichlorophosphate
T=120°C; 7 h;
参考文献
SENOMYX, INC.
Patent: US2008/306053 A1, 2008 ;
Location in patent: Page/Page column 73 ;
反应条件
trichlorophosphate
T=60°C; 1 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2006/34491 A2, 2006 ;
Location in patent: Page/Page column 134 ;
WO 2006/034491 A2
反应条件
phosphorus pentachloride; trichlorophosphate
4 h; Reflux;
参考文献
Mao, Yongjun; Lin, Nan; Tian, Wang; Han, Xiaofeng; Han, Xiaobing; Huang, Ziwei; An, Jing
Journal of Medicinal Chemistry, 2012 , vol. 55, # 3 p. 1346 - 1359
反应条件
1: 1,2-dichloro-benzene / 180 °C
2: POCl3; PCl5 / 5 h / Heating
View Scheme
参考文献
Mekheimer, Ramadan Ahmed; Elgemeie, Galal Hamza; Kappe, Thomas
Journal of Chemical Research, 2005 , # 2 p. 82 - 85
反应条件
1: TEA / 1 h / 20 °C
2: 1,2-dichloro-benzene / 180 °C
3: POCl3; PCl5 / 5 h / Heating
View Scheme
参考文献
Mekheimer, Ramadan Ahmed; Elgemeie, Galal Hamza; Kappe, Thomas
Journal of Chemical Research, 2005 , # 2 p. 82 - 85
参考文献
Gabriel
Chemische Berichte, 1918 , vol. 51, p. 1509
反应条件
ammonium acetate; acetic acid
T=140°C; 4 h;
参考文献
AVANIR PHARMACEUTICALS
Patent: WO2004/74218 A2, 2004 ;
Location in patent: Page 135 ;
