1-(2-糠酰)-2-硝基乙烯合成路线 （共 38 条）
反应条件
hydroxide; dihydrogen peroxide; 1-(n-butyl)-3-methylimidazolium triflate T=25°C; 1 h;
参考文献
Bortolini, Olga; De Nino, Antonio; Fogagnolo, Marco; Fantin, Giancarlo; Mariuolo, Loredana; Tocci, Amedeo
Chemistry Letters, 2007 , vol. 36, # 3 p. 472 - 473
反应条件
1: lithium alanate; diethyl ether 2: acetone; methyl iodide; aq. NaOH solution View Scheme
参考文献
Armitage; Ing
British Journal of Pharmacology and Chemotherapy, 1954 , vol. 9, p. 376
反应条件
1: With bromine in acetic acid 2: With pyridine in acetic acid Further stages.;
参考文献
Tuan, Dang Thanh; Tung, Dang Thanh; Langer, Peter
Synlett, 2006 , # 17 p. 2812 - 2814
反应条件
lithium aluminium tetrahydride in diethyl ether T=0°C;
参考文献
Erickson, Shawn David; Baldwin, John J.; Dolle III, Roland Ellwood; Inglese, James; Ohlmeyer, Michael H.J.; Ho, Koc-Kan; Bohnstedt, Adolph C.; Kultgen, Steven G.; Conti, Paolo Giovanni Martino; Leysen, Dirk; van der Louw, Jaap
Patent: US2004/87601 A1, 2004 ;
Location in patent: Page 26 ;
US 20040087601 A1
反应条件
lithium aluminum hydride in tetrahydrofuran
参考文献
MITSUBISHI TANABE PHARMA CORPORATION
Patent: US2012/196824 A1, 2012 ;
反应条件
in propionic acid T=40°C; 24 h;
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 52, # 11 p. 2532 - 2539,2236 - 2242
反应条件
in acetic acid T=40°C; 24 h; other solvent; Product distributionMechanism;
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 52, # 11 p. 2532 - 2539,2236 - 2242
反应条件
1: lithium alanate; diethyl ether 2: chloral 3: lithium alanate; diethyl ether View Scheme
参考文献
McCarthy; Kahl
Journal of Organic Chemistry, 1956 , vol. 21, p. 1118
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere; Reflux 2.1: water / 0.5 h / 20 °C 3.1: hydrogenchloride / N,N-dimethyl-formamide / Saturated solution 3.2: pH 11 4.1: dichloromethane / 1.5 h / 20 °C View Scheme
参考文献
CERENIS THERAPEUTICS SA; ONICIU, Daniela Carmen; DASSEUX, Jean-Louis Henri; BARBARAS, Ronald; KOCHUBEY, Valery; KOVALSKY, Dmitry; RODIN, Oleg Gennadievich; GEOFFROY, Otto; RZEPIELA, Anna
Patent: WO2012/54535 A2, 2012 ;
反应条件
triethylamine T=20°C; Michael Addition; Green chemistry;
参考文献
Agarwal, Jyoti; Naganaboina, Ram Tilak; Peddinli, Rama Krishna
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 4 p. 511 - 518
