1,3-二氮杂螺[4.4]壬烷-2,4-二酮合成路线 （共 19 条）
反应条件
1: Ba(OH)2*8H2O / H2O / 160 °C 2: HCl / Heating View Scheme
参考文献
Connors,T.A.; Ross,W.C.J.
Journal of the Chemical Society, 1960 , p. 2119 - 2132
反应条件
sodium hydroxide Heating;
参考文献
Tsang, Joseph W.; Schmied, Bernhard; Nyfeler, Rolf; Goodman, Murray
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1663 - 1668
反应条件
1: 75 percent / 3 N aq. NaOH / Heating 2: 45 percent / HCl (gas) / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 12 p. 1663 - 1668
反应条件
hydrazine hydrate 4.5 h; Heating;
参考文献
Naydenova, Emilia; Pencheva, Nevena; Popova, Julita; Stoyanov, Neyko; Lazarova, Maria; Aleksiev, Boris
Farmaco, 2002 , vol. 57, # 3 p. 189 - 194
参考文献
Gmelin Handbook: F: PerFHalOrg.1, 1.1.6.5.2, page 157 - 193
反应条件
1: Ba(OH)2*8H2O / H2O / 160 °C
2: HCl / Heating
View Scheme
参考文献
Connors,T.A.; Ross,W.C.J.
Journal of the Chemical Society, 1960 , p. 2119 - 2132
反应条件
Lawesson's reagent in toluene
6 h; Heating;
参考文献
Marinov, Marin; Minchev, Stoyan; Stoyanov, Neyko; Ivanova, Galya; Spassova, Milena; Enchev, Venelin
Croatica Chemica Acta, 2005 , vol. 78, # 1 p. 9 - 16
反应条件
1: Ba(OH)2*8H2O / H2O / 160 °C
2: H2O
View Scheme
参考文献
Connors,T.A.; Ross,W.C.J.
Journal of the Chemical Society, 1960 , p. 2119 - 2132
反应条件
sodium hydroxide
1) EtOH, reflux, 15 min; 2) reflux, 24 h; Yield given. Multistep reaction;
参考文献
Salazar, Loreto; Rubido, Julia; Espada, Modesta; Pedregal, Carmen; Trigo, Gregorio; Elguero, Jose
Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 481 - 485
