反应条件
1: 1.) NaH / 1.) DMSO, r.t., 10 min, 2.) r.t., 1 h
2: 1.) lithium diisopropylamide, 2.) hexamethylphosphoric triamide / 1.) THF, -78 deg C, 2 h, 2.) -78 deg C, 1 h, then -15 deg C, 30 min
3: 86 percent / p-toluenesulfonic acid / benzene / 1 h / Heating
4: 89 percent / hydrogen / 10 percent Pd-C / acetone / 6 h / 2574.3 Torr / Ambient temperature
View Scheme
参考文献
Tsuda; Hosoi; Goto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 1 p. 18 - 22
