6-羟基-1,4-二甲基咔唑合成路线 （共 7 条）
反应条件
1: 50 percent / triethylamine / toluene / 2 h / Heating 2: 50 percent / HNO3, acetic anhydride / 3 h / Ambient temperature 3: 81 percent / NaBH4 / methanol / 2 h / Heating 4: 45 percent / diethyl ether; methanol / 1 h / 0 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 25, # 9 p. 775 - 784
反应条件
1: 50 percent / triethylamine / toluene / 2 h / Heating 2: 50 percent / HNO3, acetic anhydride / 3 h / Ambient temperature 3: 81 percent / NaBH4 / methanol / 2 h / Heating View Scheme
参考文献
Lancelot, Jean-Charles; Letois, Bertrand; Rault, Sylvain; Robba, Max
Heterocycles, 1990 , vol. 31, # 2 p. 241 - 246
反应条件
sodium hydroxide; dihydrogen peroxide; sodium hydrogencarbonate in acetone
T=20°C; 24 h; Further stages.;
参考文献
Caruso, Anna; Voisin-Chiret, Anne Sophie; Lancelot, Jean-Charles; Sinicropi, Maria Stefania; Garofalo, Antonio; Rault, Sylvain
Heterocycles, 2007 , vol. 71, # 10 p. 2203 - 2210
参考文献
Sundaramoorthi, Rajeswari; Kansal, Vinod K.; Das, Bhupesh C.; Potier, Pierre
Journal of the Chemical Society, Chemical Communications, 1986 , # 5 p. 371 - 372
反应条件
toluene-4-sulfonic acid
参考文献
Caruso, Anna; Chimento, Adele; El-Kashef, Hussein; Lancelot, Jean-Charles; Panno, Antonella; Pezzi, Vincenzo; Saturnino, Carmela; Sinicropi, Maria Stefania; Sirianni, Rosa; Rault, Sylvain
Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 4 p. 609 - 613
反应条件
1: 50 percent / triethylamine / toluene / 2 h / Heating
2: 50 percent / HNO3, acetic anhydride / 3 h / Ambient temperature
3: 65 percent / NaBH4 / methanol / 2 h / Heating
View Scheme
参考文献
Lancelot, Jean-Charles; Letois, Bertrand; Rault, Sylvain; Robba, Max
Heterocycles, 1990 , vol. 31, # 2 p. 241 - 246
参考文献
Caruso, Anna; Chimento, Adele; El-Kashef, Hussein; Lancelot, Jean-Charles; Panno, Antonella; Pezzi, Vincenzo; Saturnino, Carmela; Sinicropi, Maria Stefania; Sirianni, Rosa; Rault, Sylvain
Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 4 p. 609 - 613
