3-氨基-4-吡唑甲酸乙酯合成路线 （共 26 条）
反应条件
hydrazine hydrate in ethanol T=20°C; 6 h;
参考文献
Deprez-Poulain, Rebecca; Cousaert, Nicolas; Toto, Patrick; Willand, Nicolas; Deprez, Benoit
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3867 - 3876
反应条件
NH2NH2•xH2O in water T=15 - 45°C; 6 h;
参考文献
INDOCO REMEDIES LIMITED; RAJADHYAKSHA, Mangesh, Narayan; KOLEKAR, Shankar, Laxman; BAVISKAR, Anil, Yuvraj; PANANDIKAR, Aditi, Milind
Patent: WO2011/64798 A1, 2011 ;
Location in patent: Page/Page column 7-8 ;
反应条件
1: isopropyl alcohol / 3 h / Reflux 2: NH2NH2•xH2O / water / 6 h / 15 - 45 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 39, p. 986,988
参考文献
Helvetica Chimica Acta, , vol. 39, p. 986,988
反应条件
sodium ethanolate; acetic acid in ethanol T=85 - 90°C; 1 h;
参考文献
Chu; Suh; Mesbah; Cutler
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 2 p. 349 - 352
反应条件
hydrogenchloride; acetic acid; sodium nitrite in ethanol 1 h; Heating;
参考文献
Toto, Patrick; Chenault, Jacques; Hakmaoui, Ahmed El; Akssira, Mohamed; Guillaumet, Gerald
Synthetic Communications, 2008 , vol. 38, # 5 p. 674 - 683
反应条件
1: With caesium carbonate in N,N-dimethyl-formamide T=110°C; 15 h; 2: With acetic acid in N,N-dimethyl-formamide T=20°C; pH=4;
参考文献
ARRAY BIOPHARMA INC.; ALLEN, Shelley; ANDREWS, Steven S.; CONDROSKI, Kevin Ronald; HAAS, Julia; HUANG, Lily; JIANG, Yutong; KERCHER, Timothy; SEO, Jeongbeob
Patent: WO2011/6074 A1, 2011 ;
Location in patent: Page/Page column 70 ;
反应条件
acetic acid in ethanol T=140°C; 0.333333 h; Microwave irradiation;
参考文献
IRM LLC; LOREN, Jon; MOLTENI, Valentina; FAN, Yi; CHOPIUK, Gregory; ALBAUGH, Pamela, A.; FLATT, Brenton, T.; SMITH, Jeffrey, M.
Patent: WO2012/34095 A1, 2012 ;
Location in patent: Page/Page column 68 ;
WO 2012/034095 A1
参考文献
Schmidt; Druey
Helvetica Chimica Acta, 1956 , vol. 39, p. 986,988
