3-氨基-4-吡唑甲酸乙酯合成路线 （共 26 条）
反应条件
sodium hydroxide; adogen 464; potassium carbonate in water; toluene Heating / reflux;
参考文献
Cephalon, Inc.
Patent: US2007/281949 A1, 2007 ;
Location in patent: Page/Page column 17-18 ;
反应条件
sodium methylate in N,N-dimethyl-formamide 3 h; Reflux;
参考文献
INDOCO REMEDIES LIMITED; RAJADHYAKSHA, Mangesh, Narayan; KOLEKAR, Shankar, Laxman; BAVISKAR, Anil, Yuvraj; PANANDIKAR, Aditi, Milind
Patent: WO2011/64798 A1, 2011 ;
Location in patent: Page/Page column 8 ;
反应条件
hydrogenchloride in water T=60°C; 0.25 h;
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
Location in patent: Page/Page column 68 ;
US 20120015962 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
CHEMOCENTRYX, INC.
Patent: WO2008/8375 A2, 2008 ;
Location in patent: Page/Page column 112-113 ;
WO 2008/008375 A2
反应条件
trans-N,N'-dimethylcyclohexane-1,2-diamine; potassium phosphate; copper(l) iodide in 1,4-dioxane T=110°C; Ullmann type arylation; 48 h; Inert atmosphere; regioselective reaction;
参考文献
Deprez-Poulain, Rebecca; Cousaert, Nicolas; Toto, Patrick; Willand, Nicolas; Deprez, Benoit
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3867 - 3876
反应条件
1: With acetic acid in ethanol T=70°C; 0.5 h; 2: With sodium hydroxide; water in ethanol; dichloromethane
参考文献
BIOVITRUM AB (publ)
Patent: WO2008/116898 A1, 2008 ;
Location in patent: Page/Page column 97 ;
反应条件
1.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 110 °C 1.2: 20 °C / pH 4 2.1: trichlorophosphate / 2 h / Reflux View Scheme
参考文献
IRM LLC; LOREN, Jon; MOLTENI, Valentina; FAN, Yi; CHOPIUK, Gregory; ALBAUGH, Pamela, A.; FLATT, Brenton, T.; SMITH, Jeffrey, M.
Patent: WO2012/34095 A1, 2012 ;
WO 2012/034095 A1
反应条件
in neat (no solvent)
参考文献
Maquestiau, A.; Eynde, J.-J. vanden
Tetrahedron, 1987 , vol. 43, # 18 p. 4185 - 4194
反应条件
trans-N,N'-dimethylcyclohexane-1,2-diamine; potassium phosphate; copper(l) iodide in 1,4-dioxane T=110°C; Ullmann type arylation; 48 h; Inert atmosphere; regioselective reaction;
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 9 p. 3867 - 3876
反应条件
copper(ll) bromide; isopentyl nitrite in acetonitrile T=50°C;
参考文献
Pfizer Inc
Patent: US2012/108619 A1, 2012 ;
Location in patent: Page/Page column 26 ;
