Beta-咔啉-3-羧酸甲酯合成路线 （共 40 条）
反应条件
trichlorophosphate
T=28°C; Bischler-Napieralski reaction; 0.5 h;
参考文献
Pal, Bikash; Jaisankar, Parasuraman; Sesha Giri, Venkatachalam; Mondal, Swastik; Mukherjee, Monika
Tetrahedron Letters, 2004 , vol. 45, # 34 p. 6489 - 6492
反应条件
1: thionyl chloride / 24 h / 0 °C / Reflux; Inert atmosphere
2: trichloroisocyanuric acid; triethylamine / N,N-dimethyl-formamide / 2 h / -20 - 0 °C / Inert atmosphere
View Scheme
参考文献
Ikeda, Reiko; Kimura, Takanori; Tsutsumi, Tatsuya; Tamura, Syunsuke; Sakai, Norio; Konakahara, Takeo
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 10 p. 3506 - 3515
反应条件
1: 64 percent / formic acid, conc. aq. HCl / 3 h / 50 °C
2: 1.) thionyl chloride, 2.) pyridinium dichromate / 1.) RT, overnight, 2.) DMF, RT, 16 h
View Scheme
参考文献
Maclaren, John A.
Australian Journal of Chemistry, 1989 , vol. 42, # 6 p. 813 - 821
反应条件
dipyridinium dichromate; thionyl chloride
1.) RT, overnight, 2.) DMF, RT, 16 h; Yield given. Multistep reaction;
参考文献
Maclaren, John A.
Australian Journal of Chemistry, 1989 , vol. 42, # 6 p. 813 - 821
反应条件
trichloroisocyanuric acid; toluene-4-sulfonic acid; triethylamine
1.) toluene, reflux, 2 h; 2.) DMF, 0 degC, 2 h; Yield given. Multistep reaction;
参考文献
Haffer, Gregor; Nickisch, Klaus; Tilstam, Ulf
Heterocycles, 1998 , vol. 48, # 5 p. 993 - 998
反应条件
1: P2O5; POCl3 / und Erwaermen des Reaktionsprodukts mit Methanol
2: aqueous HI; red phosphorus; KI / 180 °C
3: H2SO4
View Scheme
参考文献
King; Stiller
Journal of the Chemical Society, 1937 , p. 466,473
反应条件
1: aqueous HI; red phosphorus; KI / 180 °C
2: H2SO4
View Scheme
参考文献
King; Stiller
Journal of the Chemical Society, 1937 , p. 466,473
反应条件
nitrosyl chloride in chloroform
T=0°C; Product distributionMechanism;
参考文献
Salvi; Husain; Choughuley
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 2 p. 121 - 123
反应条件
hydrogenchloride
25 h; Product distribution;
参考文献
Allen; Tan; Trudell; Narayanan; Schindler; Martin; Schultz; Hagen; Koehler; Codding; Skolnick; Cook
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2343 - 2357
反应条件
1: 81 percent / N2H4*H2O / ethanol / 8 h / Heating
2: 95.4 percent / NaNO2, glac.HOAc / H2O / 1 h / 0 °C
3: 72.5 percent / tetrahydrofuran / 10 h / Heating
4: 71.76 percent / 20percent KOH / ethanol / 2 h / Heating
View Scheme
参考文献
Ikeda, Reiko; Iwaki, Toshie; Iida, Tomoko; Okabayashi, Takasumi; Nishi, Eishiro; Kurosawa, Masaki; Sakai, Norio; Konakahara, Takeo
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 636 - 646
