Beta-咔啉-3-羧酸甲酯合成路线 （共 40 条）
反应条件
sodium hydroxide
8 h;
参考文献
Tada; Saeki; Oikawa
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 5 p. 1450 - 1454
反应条件
1: 4 N NaOH / dimethylformamide / 0.17 h / 28 °C
2: dimethylformamide; H2O
View Scheme
参考文献
Mehta, Pratibha; Saxena, Anil K.; Gulati, A.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 140 - 143
反应条件
sodium
2.) 80 deg C; Yield given. Multistep reaction;
参考文献
Lippke; Schunack; Wenning; Muller
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 499 - 503
参考文献
A/S Ferrosan; Scherling AG
Patent: US4371536 A1, 1983 ;
US 4371536 A
参考文献
A/S Ferrosan; Scherling AG
Patent: US4371536 A1, 1983 ;
US 4371536 A
反应条件
lithium borohydride in tetrahydrofuran
9 h; Ambient temperature;
参考文献
Cain; Weber; Guzman; Cook; Barker; Rice; Crawley; Paul; Skolnick
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1081 - 1091
反应条件
1: 82 percent / LiBH4 / tetrahydrofuran / 9 h / Ambient temperature
2: 70 percent / MnO2 / acetonitrile / 4.5 h / Heating
3: 96 percent / tetrahydrofuran / 2.5 h / 25 °C
4: 80 percent / MnO2 / acetonitrile / 1.5 h / Heating
View Scheme
参考文献
Cain; Weber; Guzman; Cook; Barker; Rice; Crawley; Paul; Skolnick
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1081 - 1091
反应条件
sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.5 h;
参考文献
Cao, Rihui; Chen, Qi; Hou, Xuerui; Chen, Hongsheng; Guan, Huaji; Ma, Yan; Peng, Wenlie; Xu, Anlong
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4613 - 4623
反应条件
ammonia in methanol
48 h;
参考文献
Cain, Michael; Guzman, Fil; Cook, James M.; Rice, Kenner C.; Skolnick, Phil
Heterocycles, 1982 , vol. 19, # 6 p. 1003 - 1007
反应条件
1.1: hydrazine hydrate / pentan-1-ol / 7 h / 150 °C
2.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C
3.1: o-xylene / 1 h / 160 °C
4.1: water; potassium hydroxide / ethanol / 2 h / Reflux
5.1: pyridine / 5 h / 20 °C
5.2: 1 h / 20 °C / Saturated solution
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux
6.2: 2 h / 20 °C
View Scheme
参考文献
Ikeda, Reiko; Iwaki, Toshie; Iida, Tomoko; Okabayashi, Takasumi; Nishi, Eishiro; Kurosawa, Masaki; Sakai, Norio; Konakahara, Takeo
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 636 - 646
